Publications by authors named "Karenne Fru"
Wdr59 promotes or inhibits TORC1 activity depending on cellular context.
Proc Natl Acad Sci U S A
January 2023
Target of Rapamycin Complex I (TORC1) is a central regulator of metabolism in eukaryotes that responds to a wide array of negative and positive inputs. The GTPase-activating protein toward Rags (GATOR) signaling pathway acts upstream of TORC1 and is comprised of two subcomplexes. The trimeric GATOR1 complex inhibits TORC1 activity in response to amino acid limitation by serving as a GTPase-activating protein (GAP) for the TORC1 activator RagA/B, a component of the lysosomally located Rag GTPase.
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- * Research involved analyzing gene expression and DNA methylation in biopsy samples from healthy women and those with high (HEI) or low integrin expression (LEI), revealing distinct transcriptional and epigenetic changes in the LEI group with 396 differentially expressed genes.
- * The study identified 14 genes with altered methylation patterns associated with LEI, with the aryl hydrocarbon receptor (AHR) showing increased expression, potentially serving as a diagnostic marker for women with
Article Synopsis
- - This study investigates how macaque granulosa cells produce mineralocorticoids during ovulation, particularly following the administration of hCG, a hormone that triggers ovulation.
- - After hCG injection, levels of progesterone and 17alpha-hydroxyprogesterone rise quickly, while key metabolites like 11-deoxycorticosterone and cortisol increase over time, indicating active hormone synthesis.
- - The findings suggest that the mineralocorticoid receptor is crucial for progesterone production by granulosa cells in response to ovulation, highlighting a complex interplay of hormones during the luteal phase.