Publications by authors named "Karen Soares Trinta"
Process development and characterization of recombinant nucleocapsid protein for its application on COVID-19 diagnosis.
Protein Expr Purif
July 2023
COVID-19 pandemic was caused by the severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2). The nucleocapsid (N) protein from Sars-CoV-2 is a highly immunogenic antigen and responsible for genome packing. Serological assays are important tools to detect previous exposure to SARS-CoV-2, complement epidemiological studies, vaccine evaluation and also in COVID-19 surveillance.
View Article and Find Full Text PDFArticle Synopsis
- Researchers assessed immune response profiles in SARS-CoV-2 infected patients by examining 71 biomarkers across different clinical groups: asymptomatic, mild, and severe cases.
- They found that certain angiogenesis and cardiovascular disease biomarkers were significantly elevated in severe cases compared to the other groups, indicating distinct immune profiles.
- The study highlights important differences in cytokines and chemokines among patients, providing insights into potential prognostic markers for understanding disease severity in COVID-19 infections.
Background: Chikungunya virus (CHIKV) has caused worldwide epidemics that impose a major burden on health systems. Approximately half of infected individuals develop chronic debilitating arthralgia, affecting their quality of life. Here, we identified the relevant clinical and demographic variables in the acute phase of CHIKV infection prospectively linked to chronic arthralgia to elaborate a prognostic scoring system.
View Article and Find Full Text PDFEosinophils involved in fulminant hepatic failure are associated with high interleukin-6 expression and absence of interleukin-5 in liver and peripheral blood.
Liver Int
April 2009
Background/aims: Although eosinophils are considered to play an important role in the pathogenesis of various parasitic, allergic and autoimmune digestive diseases, their role in fulminant hepatic failure (FHF) is unknown. Our contribution was to identify and quantify eosinophils and cytokine levels [interleukin (IL)-6, IL-5 and macrophage inflammatory protein (MIP)-1alpha] in liver parenchyma and peripheral blood from FHF patients at pre- and post-transplantation steps.
Methods: Histochemical methods were used to identify/quantify eosinophils in liver samples.