Performance of ultrasound as a second line test to serum CA125 in ovarian cancer screening.

Objective: To assess the performance of ultrasonography in a multimodal ovarian cancer screening strategy.

Design: Prospective ovarian cancer screening trial between December 1986 and June 1993.

Setting: General practice, occupational health departments and an ovarian cancer screening clinic at a London teaching hospital.

Prospective study using the risk of ovarian cancer algorithm to screen for ovarian cancer.

Purpose: To evaluate prevalence screening in the first prospective trial of a new ovarian cancer screening (OCS) strategy (risk of ovarian cancer or ROC algorithm) on the basis of age and CA125 profile.

Patients And Methods: Postmenopausal women, > or = 50 years were randomly assigned to a control group or screen group. Screening involved serum CA125, interpreted using the ROC algorithm.