Publications by authors named "Karen Samples"
Article Synopsis
- The study assessed how a weekly tumor board meeting influences the treatment of patients with gynecologic cancers by analyzing medical records from January 2004 to December 2006 for 741 patients.
- The tumor board reviewed pathology for 526 patients, leading to a change in diagnosis for 27% of cases, which altered clinical management in 74% of these instances, impacting 20% of all reviews.
- Radiology reviews, mostly aimed at confirming ongoing cancer, confirmed malignancy in 74% of cases and resulted in a new diagnosis or upstaging for 10% of the reviewed imaging studies.
The yeast Saccharomyces cerevisiae alpha-factor pheromone receptor (Ste2p) was used as a model G protein-coupled receptor (GPCR). A 73-mer multidomain fragment of Ste2p (residues 267-339) containing the third extracellular loop, the seventh transmembrane domain, and 40 residues of the cytosolic tail (E3-M7-24-T40) was biosynthesized fused to a carrier protein. The multidomain fusion protein (designated M7FP) was purified to near homogeneity as judged by HPLC and characterized by mass spectrometry.
View Article and Find Full Text PDFThe yeast Saccharomyces cerevisiae undergoes cell fusion during sexual conjugation to form diploid cells. The haploids participating in this process signal each other through secreted peptide-mating factors (alpha-factor and a-factor) that are recognized by G-protein-coupled receptors. The receptor (Ste2p) recognizing the tridecapeptide alpha-factor is used as a model system in our laboratory to understand various aspects of peptide-receptor interactions and receptor structure.
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