Pharmacologic Treatment of Hypertensive Urgency in the Outpatient Setting: A Systematic Review.

Background: Hypertensive urgency (HU), defined as acute severe uncontrolled hypertension without end-organ damage, is a common condition. Despite its association with long-term morbidity and mortality, guidance regarding immediate management is sparse. Our objective was to summarize the evidence examining the effects of antihypertensive medications to treat.

Zonisamide concentrations during pregnancy.

Objective: To describe a series of serum concentrations of zonisamide in a pregnant woman.

Case Summary: A 30-year-old woman with primary generalized tonic-clonic seizures and myoclonic jerks was taking zonisamide 200 mg daily as her sole antiepileptic agent when she conceived. She continued on zonisamide throughout her pregnancy.

Beta-blocker medication usage in older women after myocardial infarction.

Purpose: The purpose of this study was to assess demographic characteristics of women prescribed beta-blocker (beta-blocker) medication and compare to those not using beta-blocker medication, and to determine if there are differences in depression and fatigue among women who used beta-blockers compared to nonusers 6-12 months after myocardial infarction (MI).

Data Sources: This was a descriptive cross-sectional study of 84 women (61 using beta-blockers and 23 not using beta-blockers) aged 65 and older who were 6-12 months post-MI. Women had their height and weight measured and completed a Demographic Health Form, the Geriatric Depression Scale, and the Revised Piper Fatigue Scale (RPFS).

Impact of topiramate on serum bicarbonate concentrations in adults.

Background: Topiramate is an antiepileptic medication with multiple pharmacologic effects, including inhibition of carbonic anhydrase activity. It is associated with metabolic acidosis in both children and adults.

Objective: To evaluate the incidence and magnitude of the effect of topiramate on serum bicarbonate concentrations in an adult population.