Publications by authors named "Karen Rees"

Article Synopsis
  • People with heart failure face significant challenges including low exercise tolerance, poor quality of life, increased hospital admissions, and high healthcare costs; exercise-based cardiac rehabilitation (ExCR) has shown potential benefits in these areas according to a 2018 review.
  • The objectives of the new review were to evaluate the effects of ExCR on mortality, hospital admissions, and health-related quality of life among adults with heart failure.
  • The study included randomized controlled trials that compared ExCR interventions to no exercise control, focusing on patients with both heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF).
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Background: Interventions incorporating meditation to address stress, anxiety, and depression, and improve self-management, are becoming popular for many health conditions. Stress is a risk factor for cardiovascular disease (CVD) and clusters with other modifiable behavioural risk factors, such as smoking. Meditation may therefore be a useful CVD prevention strategy.

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The COVID-19 pandemic triggered disruptions to health care and lifestyles that could conceivably impact diabetes management. We set out to identify the impact of disruptions caused by COVID-19 on clinical outcomes in people with diabetes. We performed a systematic review of the available literature in the MEDLINE and OVID databases from Jan 1, 2020, to June 7, 2023, and included 138 studies (n>1 000 000 people).

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Aims: Despite strong evidence, access to exercise-based cardiac rehabilitation (ExCR) remains low across global healthcare systems. We provide a contemporary update of the Cochrane review randomized trial evidence for ExCR for adults with heart failure (HF) and compare different delivery modes: centre-based, home-based (including digital support), and both (hybrid).

Methods And Results: Databases, bibliographies of previous systematic reviews and included trials, and trials registers were searched with no language restrictions.

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Aims: Coronary heart disease is the most common reason for referral to exercise-based cardiac rehabilitation (CR) globally. However, the generalizability of previous meta-analyses of randomized controlled trials (RCTs) is questioned. Therefore, a contemporary updated meta-analysis was undertaken.

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Background: There is increasing interest in the association between nature, health and wellbeing. Gardening is a popular way in which interaction with nature occurs and numerous gardening projects aim to facilitate wellbeing among participants. More research is needed to determine their effectiveness.

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Aim: To identify, appraise and synthesize the available evidence on the impact of the coronavirus disease 2019 (COVID-19) pandemic and lockdown (LD) on glycaemic control in people with diabetes.

Materials And Methods: We searched multiple databases up to 2 February 2021 for studies reporting HbA1c, time in range (TIR), average or fasting glucose, severe hypoglycaemia and diabetic ketoacidosis. Data were pooled using random effects meta-analysis and are presented as mean difference (MD) with 95% confidence intervals (CI).

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Since the 1980s, there has been an increasing acknowledgement of the importance of recognising the ethical dimension of clinical decision-making. Medical professional regulatory authorities in some countries now include ethical knowledge and practice in their required competencies for undergraduate and post graduate medical training. Educational interventions and clinical ethics support services have been developed to support and improve ethical decision making in clinical practice, but research evaluating the effectiveness of these interventions has been limited.

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Article Synopsis
  • The study investigated the effects of fluid intake on outcomes in adults with pneumonia, focusing on whether dehydration impacts mortality rates.
  • A systematic review analyzed various studies, revealing that dehydration was associated with higher medium-term mortality, with a meta-analysis showing dehydrated pneumonia patients had double the odds of dying compared to those who were hydrated.
  • The findings indicated a consistent link between dehydration and increased mortality across different pneumonia types, age groups, and healthcare settings, suggesting that sufficient fluid intake may be critical for patient recovery.
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Objectives: To determine if and to what degree asthma may predispose to worse COVID-19 outcomes in order to inform treatment and prevention decisions, including shielding and vaccine prioritisation.

Design: Systematic review and meta-analysis.

Setting: Electronic databases were searched (October 2020) for clinical studies reporting at least one of the following stratified by asthma status: risk of infection with SARS-CoV-2; hospitalisation, intensive care unit (ICU) admission or mortality with COVID-19.

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Article Synopsis
  • Coronary heart disease (CHD) is a leading global cause of death, and with decreasing mortality rates, more people are living with CHD and need effective symptom management.
  • The main focus of the study was to evaluate how exercise-based cardiac rehabilitation (CR) compares to no exercise control in terms of its clinical effectiveness and cost-effectiveness on mortality, morbidity, and health-related quality of life for CHD patients.
  • The review incorporated 85 trials with over 23,000 participants, found new evidence supporting exercise-based interventions, and stratified data analysis to better understand outcomes over various follow-up durations.
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Background: This review was commissioned by the World Health Organization and presents a summary of the latest research evidence on the impact of coronavirus disease 2019 (COVID-19) on people with diabetes (PWD).

Purpose: To review the evidence regarding the extent to which PWD are at increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and/or of suffering its complications, including associated mortality.

Data Sources: We searched the Cochrane COVID-19 Study Register, Embase, MEDLINE, and LitCOVID on 3 December 2020.

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Background: Diet plays a major role in the aetiology of cardiovascular disease (CVD) and as a modifiable risk factor is the focus of many prevention strategies. Recently vegan diets have gained popularity and there is a need to synthesise existing clinical trial evidence for their potential in CVD prevention.

Objectives: To determine the effectiveness of following a vegan dietary pattern for the primary and secondary prevention of CVD.

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Background: Diet plays a major role in cardiovascular disease (CVD) risk.

Objectives: To determine the effectiveness of a Mediterranean-style diet for the primary and secondary prevention of CVD.

Methods: We searched for randomised controlled trials (RCTs) of Mediterranean-style diets in healthy adults and those at increased risk of CVD (primary prevention) and with established CVD (secondary prevention).

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Treatment in an intensive care unit can be life-saving but it can be distressing and not every patient can benefit. Decisions to admit a patient to an intensive care unit are complex. We wished to explore how the decision to refer or admit is experienced by those involved, and undertook a systematic review of the literature to answer the research question: What are the experiences of health care professionals, patients, and families, of the process of referral and admission to an intensive care unit? Twelve relevant studies were identified, and a thematic analysis was conducted.

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Objectives: This study performed a contemporary systematic review and meta-analysis of exercise-based cardiac rehabilitation (ExCR) for heart failure (HF).

Background: There is an increasing call for trials of models of ExCR for patients with HF that provide alternatives to conventional center-based provision and recruitment of patients that reflect a broader HF population.

Methods: The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, and PsycINFO databases were searched between January 2013 and January 2018.

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This paper was originally published under a standard licence. This has now been amended to a CC BY licence in the PDF and HTML.

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Background: The Seven Countries study in the 1960s showed that populations in the Mediterranean region experienced lower coronary heart disease (CHD) mortality probably as a result of different dietary patterns. Later observational studies have confirmed the benefits of adherence to a Mediterranean dietary pattern on cardiovascular disease (CVD) risk factors but clinical trial evidence is more limited.

Objectives: To determine the effectiveness of a Mediterranean-style diet for the primary and secondary prevention of CVD.

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Background: Chronic heart failure (HF) is a growing global health challenge. People with HF experience substantial burden that includes low exercise tolerance, poor health-related quality of life (HRQoL), increased risk of mortality and hospital admission, and high healthcare costs. The previous (2014) Cochrane systematic review reported that exercise-based cardiac rehabilitation (CR) compared to no exercise control shows improvement in HRQoL and hospital admission among people with HF, as well as possible reduction in mortality over the longer term, and that these reductions appear to be consistent across patient and programme characteristics.

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Background: Omega-6 fats are polyunsaturated fats vital for many physiological functions, but their effect on cardiovascular disease (CVD) risk is debated.

Objectives: To assess effects of increasing omega-6 fats (linoleic acid (LA), gamma-linolenic acid (GLA), dihomo-gamma-linolenic acid (DGLA) and arachidonic acid (AA)) on CVD and all-cause mortality.

Search Methods: We searched CENTRAL, MEDLINE and Embase to May 2017 and clinicaltrials.

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Children and adolescents with overweight and obesity are a global health concern. This is an integrative overview of six Cochrane systematic reviews, providing an up-to-date synthesis of the evidence examining interventions for the treatment of children and adolescents with overweight or obesity. The data extraction and quality assessments for each review were conducted by one author and checked by a second.

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