Effects of temporary low-dose galactose supplements in children aged 5-12 y with classical galactosemia: a pilot study.

Background: Classical galactosemia is caused by severe galactose-1-phosphate uridyltransferase deficiency. Despite life-long galactose-restriction, many patients experience long-term complications. Intoxication by galactose and its metabolites as well as over-restriction of galactose may contribute to the pathophysiology.