Publications by authors named "Karen P Mason"

Sublethal γ irradiation eliminates CD8+ T cell mediated memory responses. In this work, we explored how these memory responses could be rescued in the aftermath of such exposure. We utilized two models of CD8+ T cell mediated immunity: a mouse model of Listeria monocytogenes (LM) infection in which CD8+ T cells specific for LM expressed antigens (Listeriolysin O, LLO) can be tracked, and a murine skin graft model in which CD8+ T cells mediate rejection across a MHC class I (D(d)) disparity.

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Article Synopsis
  • Front-line chemotherapeutics like doxorubicin can lead to oxidative stress and cardiotoxicity, which traditional antioxidants have struggled to fully address.
  • Researchers developed a syngeneic rat model (SHR/SST-2) to simultaneously study tumor growth and the heart's response to treatment, using cytokine measurements.
  • They found that both dexrazoxane and Mito-Tempol improved heart health without affecting cancer treatment efficacy, indicating these agents help protect the heart by enhancing pro-survival mechanisms while also identifying specific biomarkers of cardiotoxicity.
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Sublethal total body γ irradiation (TBI) of mammals causes generalized immunosuppression, in part by induction of lymphocyte apoptosis. Here, we provide evidence that a part of this immune suppression may be attributable to dysfunction of immune regulation. We investigated the effects of sublethal TBI on T cell memory responses to gain insight into the potential for loss of vaccine immunity following such exposure.

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