Ipilimumab and nivolumab for recurrent neuroendocrine cervical carcinoma.

Neuroendocrine carcinoma of the cervix is a rare subtype of cervical cancer with a poor prognosis. Primary treatment of this disease involves a combination of surgery, chemotherapy, and radiation. The majority of patients will experience disease recurrence, for which there exist no treatment guidelines.

Surgery and Platinum/Etoposide-Based Chemotherapy for the Treatment of Epithelioid Trophoblastic Tumor.

Objective: Epithelioid trophoblastic tumor (ETT) is a rare variant of gestational trophoblastic neoplasia that develops from chorionic-type intermediate trophoblast, simulates carcinoma, presents years after a pregnancy event, is associated with low or normal human chorionic gonadotropin levels, and is relatively resistant to chemotherapy. Our aim was to identify the role of surgery in combination with platinum/etoposide-based chemotherapy in the management of both localized and metastatic ETT.

Methods: A retrospective review was performed of women with ETT treated at a gestational trophoblastic disease center from 2010 to 2016.

Diabetes and oral disease: implications for health professionals.

"Diabetes and Oral Disease: Implications for Health Professionals" was a one-day conference convened by the Columbia University College of Dental Medicine, the Columbia University College of Physicians and Surgeons, and the New York Academy of Sciences on May 4, 2011 in New York City. The program included an examination of the bidirectional relationship between oral disease and diabetes and the interprofessional working relationships for the care of people who have diabetes. The overall goal of the conference was to promote discussion among the healthcare professions who treat people with diabetes, encourage improved communication and collaboration among them, and, ultimately, improve patient management of the oral and overall effects of diabetes.

Oral microbial biofilm stimulation of epithelial cell responses.

Oral bacterial biofilms trigger chronic inflammatory responses in the host that can result in the tissue destructive events of periodontitis. However, the characteristics of the capacity of specific host cell types to respond to these biofilms remain ill-defined. This report describes the use of a novel model of bacterial biofilms to stimulate oral epithelial cells and profile select cytokines and chemokines that contribute to the local inflammatory environment in the periodontium.

U.S. dental school applicants and enrollees, 2009 entering class.

Over the past two decades, interest in dentistry in the United States has shown a steady period of growth. There were 12,210 individuals who applied to the 2009 entering class of U.S.

Novel model for multispecies biofilms that uses rigid gas-permeable lenses.

Oral biofilms comprise complex multispecies consortia aided by specific inter- and intraspecies interactions occurring among commensals and pathogenic bacterial species. Oral biofilms are primary initiating factors of periodontal disease, although complex multifactorial biological influences, including host cell responses, contribute to the individual outcome of the disease. To provide a system to study initial stages of interaction between oral biofilms and the host cells that contribute to the disease process, we developed a novel in vitro model system to grow biofilms on rigid gas-permeable contact lenses (RGPLs), which enable oxygen to permeate through the lens material.

Guidinq change one school at a time.

Liaison teams have been developed in order to ensure that national initiatives identified in the American Dental Education Association's Commission on Change and Innovation (ADEA CCI) are implemented at the level of individual schools. Teams of four faculty members each have been identified at 43 United States and Canadian schools. These teams receive training at ADEA annual meeting and at summer institutes.

What the ADEA CCI series of articles means to me: reflections of a mid-career dental faculty member.

In this reflection article, Dr. Karen Novak, a mid-career faculty member at a U.S.

Effects of caloric restriction on inflammatory periodontal disease.

Objective: Dietary caloric restriction (CR) has been found to reduce systemic markers of inflammation and may attenuate the effects of chronic inflammatory conditions. The purpose of this study was to examine the effects of long-term CR on naturally occurring chronic inflammatory periodontal disease in a nonhuman primate model.

Methods: The effects of long-term CR on extent and severity of naturally occurring chronic periodontal disease, local inflammatory and immune responses, and periodontal microbiology, were evaluated in a cohort of 81 (35 female and 46 male; 13-40 y of age) rhesus monkeys (Macaca mulatta) with no previous exposure to routine oral hygiene.

Periodontal bacterial profiles in pregnant women: response to treatment and associations with birth outcomes in the obstetrics and periodontal therapy (OPT) study.

Background: A recent clinical trial (Obstetrics and Periodontal Therapy [OPT] Study) demonstrated that periodontal therapy during pregnancy improved periodontal outcomes but failed to impact preterm birth. The present study evaluated seven target bacteria, Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans), Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia (previously T. forsythensis), Prevotella intermedia, Campylobacter rectus, and Fusobacterium nucleatum, in subgingival dental plaque of pregnant women in the OPT Study and their association with birth outcomes.

The effects of a calorie-reduced diet on periodontal inflammation and disease in a non-human primate model.

Background: Low-calorie diets are commonplace for reducing body weight. However, no information is available on the effects of a reduced-calorie diet on periodontal inflammation and disease. The purpose of this study was to evaluate the clinical effects of a long-term calorie-restriction (CR) diet on periodontitis in an animal model of periodontitis.

Should we treat periodontal disease during gestation to improve pregnancy outcomes?

Until recently many physicians in the United States including obstetrician gynecologists have been relatively unconcerned with oral health. During most physical examinations, the oral cavity is given only a rudimentary examination. With the recognition of the oral-systemic health care link, physicians have been keenly interested in the findings from their dental colleagues in periodontal medicine which have convincingly linked periodontal disease with such diverse systemic health complications as aging, Alzheimer disease, cardiovascular disease, diabetes, and also pregnancy complications including low birth weight, preterm delivery, preeclampsia, and early pregnancy loss.

Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria.

The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible.

Periodontitis and gestational diabetes mellitus: exploring the link in NHANES III.

Objectives: The authors hypothesized that women with a history of gestational diabetes mellitus (GDM) during pregnancy would exhibit more severe periodontal disease than controls without a history of diabetes during pregnancy.

Methods: Data from NHANES Ill provided information for 4,244 women ages 20-59. One hundred and thirteen had a history of GDM (GDM+), while 4,131 had no history of diabetes before or during their pregnancies (GDM-).

Factors associated with comprehensive dental care following an initial emergency dental visit.

Purpose: The purpose of this study was to characterize the patient population utilization of a dental home as grouped by: (1) age; (2) sex; and (3) payment method.

Methods: A retrospective chart review of 1,020 patients, who initially presented for an emergency visit, was performed. From the original data pool, 2 groups were delineated: (1) those patients who returned for comprehensive dental care; and (2) those who did not return for comprehensive dental care.

Agency nurse assessment for competency.

The goal of this study is to make the agency nurse's performance standards equivalent to that of hospital nurse levels of performance based in hospital staff observation to provide continuity of safe, quality patient care. To attain this goal, the following should be done: (1) develop orientation process that includes module for general orientation; (2) agencies pay for nurse orientation to include 8-hour session and a 4-hour skills assessment; (3) develop flip cards for agency nurses as a resource tool; (4) annual general assessment for hospital employees to be completed by agency nurses; and (5) develop process to document and distribute information to charge nurses about agency nurse competency. Leaders should ensure that the process for identifying and managing are defined and implemented.

Students' perceived importance of diversity exposure and training in dental education.

Intercultural competence is an important component of the doctor-patient relationship in the multicultural climate evolving in the United States. We hypothesized that 1) exposure to racial and ethnic diversity in the student body, faculty, staff, and patient population in dental school and 2) a dental school curriculum that includes presentations on issues concerning racial and ethnic diversity will contribute to students' feeling more competent and confident to enter the multicultural work environment that is rapidly developing in the United States. A Likert-type scale questionnaire was administered to 627 fourth-year dental students enrolled in seven dental schools representing geographically diverse regions of the United States.

A model for assessing the ethical environment in academic dentistry.

Weber's "Institutional Ethics Audit" model was designed as a tool for assessment of an organization's effort to institutionalize ethics into its operations. In this model, the overall ethical environment of an organization is evaluated through an assessment of its 1) ethical cultures, 2) ethics policy, 3) enforcement mechanisms, and 4) ethical training. Assessment of these components allows the organization to be placed along a continuum that spans aethical firms, compliance firms, emerging firms, and integrity firms.

Identification of factors influencing matriculation decisions by dental school applicants.

Recent dental school surveys have indicated a slight decrease in the overall number of dental school applicants. As a result, competition for the most highly qualified students is increasing among dental schools. A number of factors may contribute to an applicant's decision on where to matriculate, such as tuition costs, cost of living in an area, location of the dental school, reputation, availability of financial aid, and the school's facilities.