Publications by authors named "Karen Moreno-Medina"

Congenital heart disease is the most common congenital condition worldwide, with a prevalence of 80 cases per 10 000 live births. In addition to perinatal morbidity and mortality, it entails long-term consequences such as multiple surgeries, prolonged hospitalizations, lifelong cardiac follow-up, reduced quality of life, risk of heart failure, and premature mortality in adulthood. This significant health and economic burden on healthcare systems and families highlights the relevance of evaluating the cost-effectiveness of methods for early detection of this condition.

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Article Synopsis
  • High driving pressure (DP) during mechanical ventilation can negatively impact outcomes in pediatric patients with acute respiratory distress syndrome (PARDS), particularly regarding 28-day mortality rates.
  • A study of 184 intubated children showed that those with a DP greater than 15 cm H2O at 72 hours had a higher risk for mortality and longer ventilation duration.
  • Key findings included that lower tidal volumes were linked to decreased mortality risk, while higher plateau pressures in non-survivors highlighted the importance of managing ventilation parameters effectively.*
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Pericardial effusions requiring pericardiocentesis have multiple causes that vary among geographical regions and health contexts. This procedure can be performed for diagnostic or therapeutic indications. The purpose of this study was to identify the principal causes of pericardial effusions and indications for pericardiocentesis, exploring differences among groups.

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Objectives: Serum lactate is a useful biomarker of tissue perfusion in critically ill patients. We evaluated the behavior of serum lactate in children in the pediatric intensive care unit (PICU) immediately after liver transplantation and its association with surgical complications, graft dysfunction and 90-day mortality.

Materials And Methods: A prospective observational study carried out between November 2009 and December 2019.

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Objectives: Globally congenital heart disease mortality is declining, yet the proportion of infant deaths attributable to heart disease rises in Colombia and other middle-sociodemographic countries. We aimed to assess the accessibility of paediatric cardiac surgery (PCS) to children <18 years of age in 2016 in the South American country of Colombia.

Methods: In Bogotá, Colombia, a multi-national team used cross-sectional and retrospective cohort study designs to adapt and evaluate 4 health system indicators at the national level: first, the population with timely geographic access to an institution providing PCS; second, the number of paediatric cardiac surgeons; third, this specialized procedure volume and its national distribution; and fourth, the 30-day perioperative mortality rate after PCS in Colombia.

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Introduction: Gastric pseudotumors are rare entities whose clinical presentation resembles typical gastric neoplasias, often making them unrecognized unless other causes are considered.

Presentation Of Case: We present a case report of a patient that debuts with dysphagia, with an abdominal computed axial tomography (CAT) scan revealing a mass at the gastro-esophageal junction suggestive of malignant origin, with studies revealing it to be Immunoglobulin G4-related (IgG4).

Discussion: The diagnosis and identification of IgG4-related gastric pseudotumors is very complicated, often and most commonly an incidental diagnosis upon histologic analysis, as is the situation in this case.

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Article Synopsis
  • The study investigates the quality of life (QoL) in children with infrequent congenital heart defects (I-CHD) and how it changes over one year, comparing self-reports from children and reports from their caregivers.
  • Data was collected from a cohort of children diagnosed with I-CHD in Colombia, utilizing a clinical psychology assessment and the Pediatric Quality of Life Inventory (PedsQL) to measure QoL at baseline and after one year.
  • Results showed that children reported higher QoL scores than their caregivers at both time points, with notable differences in cardiac module scores at baseline but no significant changes in general module scores over one year.
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Background: Ebstein anomaly (EA) is a heterogeneous congenital heart defect (CHD), frequently accompanied by diverse cardiac and extracardiac comorbidities, resulting in a wide range of clinical outcomes.

Hypothesis: Phenotypic characterization of EA patients has the potential to identify variables that influence prognosis and subgroups with distinct contributing factors.

Methods: A comprehensive cross-sectional phenotypic characterization of 147 EA patients from one of the main referral institutions for CHD in Colombia was carried out.

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