Background: Approximately 40% of patients with chronic idiopathic urticaria have antibodies to the alpha subunit of the high-affinity IgE receptor. CD203c is a basophil activation marker known to be upregulated by cross-linking of the FcepsilonRIalpha receptor and may serve as a useful marker to identify these patients.
Objective: The primary objective was to assess the affect of sera from patients with chronic idiopathic urticaria on basophil CD203c expression.