Evaluation of Pepsinogen I as a Biomarker of Drug-induced Gastric Mucosal Injury in Cynomolgus Monkeys.

Gastric mucosal injury is frequently observed in nonclinical studies of nonhuman primates. Because microscopic evaluation of stomach is generally a terminal procedure, our objective was to determine whether serum pepsinogen I (PG I) could serve as a noninvasive biomarker for detection of gastric mucosal injury in monkey. Serum PG I was measured using a commercial human immunoassay in cynomolgus monkeys ( n = 166) prior to dosing and/or terminally in 11 studies of up to 1 month duration.

Isolated mononeuropathy multiplex--a rare manifestation of intravascular large B-cell lymphoma.

Intravascular large B-cell lymphoma, also known as angiotrophic large cell lymphoma, is a rare disorder where neoplastic lymphoid cells proliferate within the walls of small- to medium-sized blood vessels. Peripheral neuropathy and other neurological manifestations, including stroke and dementia, are common, but cases of isolated multiple mononeuropathies in the absence of systemic symptoms are distinctly rare. We present an unusual case of biopsy-proved angiotrophic large cell lymphoma presenting exclusively with multiple mononeuropathies.

Headaches that kill: a retrospective study of incidence, etiology and clinical features in cases of sudden death.

Objective: The study objective was to analyze cases of sudden death that presented to the National Deptartment of Clinical Neurosciences, Ireland, over a 10-year period (1997-2006) where headache was the presenting symptom.

Background: Headache is a common yet challenging presentation in clinical neurology. In the vast majority of cases, the cause is trivial and reversible-however, in a few patients it may be indicative of a more sinister intracranial process.

Co-prescription of gastro-protectants in hospitalized patients: an analysis of what we do and what we think we do.

Background: Proton pump inhibitors (PPIs) reduce the risk of upper gastrointestinal hemorrhage (UGIH) associated with the use of many medications.

Goals: To examine how clinicians perceive such risk and whether PPI co-prescribing is based on an accurate assessment.

Study Methods: Clinicians in a single teaching hospital were asked to estimate risk of UGIH and comment on PPI co-prescription in hypothetical patients.