Publications by authors named "Karen Larissa Pereira de Castro"
Article Synopsis
- Recognition of the intron branchpoint in spliceosome assembly is crucial for mRNA structure and quantity, involving a branchpoint sequence motif that varies across eukaryotic genomes.
- SF1 and QKI proteins compete for recognition of a specific intron branchpoint sequence (ACUAA), where SF1 promotes exon inclusion while QKI represses it, affecting splicing outcomes.
- The findings suggest that QKI acts as a splicing repressor by blocking SF1 binding at dual branchpoints, indicating a co-evolution of branchpoint sequences for precise regulation of gene expression in diverse organisms.
Micrurus surinamensis is a semi-aquatic coral snake found in primary forest region and can cause relevant human accidents. In this work we investigated the toxic and antigenic activities of the Peruvian Micrurus surinamensis venom (MsV). We found that MsV show hyaluronidase activity but lack LAAO and PLA enzymatic activities.
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- - The study investigates the role of alternative splicing in the development of the three embryonic germ layers using RNA-Seq on human embryonic stem cells and their derived lineages, identifying distinct splicing programs for each lineage.
- - Significant differences in splicing were found primarily between definitive endoderm and cardiac mesoderm, with an integrative analysis revealing RNA binding proteins that regulate these splicing events, particularly highlighting Quaking (QKI) in cardiac mesoderm specification.
- - QKI knockout led to disruptions in the cardiac mesoderm splicing program and the formation of myocytes by reducing splice variants of the BIN1 gene, emphasizing QKI's role in managing this process through specific RNA interactions and chromatin
Article Synopsis
- Accidents involving snake bites are serious, requiring treatment with coral antivenom, which is challenging to produce due to limited availability of specific snake venoms.
- Researchers propose a new immunization method that combines natural venom and synthetic components to increase the effectiveness of coral antivenom using a rabbit model.
- The study shows that this approach not only produces effective antibodies but also offers a potential solution to reduce venom dependency in antivenom production in Brazil.
Background: Hadruroides lunatus is the most abundant scorpion species in the Peruvian central coast, where most of the accidents involving humans are registered. In spite of its prevalence, there are only very few studies on H. lunatus envenomation.
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