Systemic Therapy in Advanced Cutaneous Squamous Cell Carcinoma (CSCC): The Roswell Park Experience and a Review of the Literature.

Objectives: Treatment of locally advanced unresectable or metastatic cutaneous squamous cell carcinoma (mCSCC) is suboptimal with a paucity of robust data on systemic therapy. This retrospective study aimed to evaluate the efficacy and outcomes of patients with locally advanced unresectable or mCSCC treated with systemic therapy.

Methods: Records of patients with CSCC treated with systemic therapy from January 2001 to January 2011 were reviewed.

Dose rounding of ipilimumab in adult metastatic melanoma patients results in significant cost savings.

Purpose: To assess cost savings incurred with a dose rounding process that was implemented for ipilimumab. Secondarily, to assess response rates, patient tolerance, and adverse effects associated with ipilimumab upon implementation of dose rounding.

Methods: All patients with a diagnosis of metastatic melanoma and who received at least one dose ipilimumab were included for analysis.