Publications by authors named "Karen L O'Sullivan"
Article Synopsis
- The study investigates the use of mesenchymal precursor cells (MPCs) during left ventricular assist device (LVAD) implantation to enhance cardiac recovery in patients with advanced heart failure.
- It involved a randomized phase 2 clinical trial with 159 participants across 19 North American centers, where patients received either MPC injections or a sham treatment.
- Results showed that the MPCs did not significantly improve the rate of successful temporary weaning from LVAD support and no major safety concerns were reported during the 1-year follow-up.
Importance: Stroke is a major complication of surgical aortic valve replacement (SAVR).
Objective: To determine the efficacy and adverse effects of cerebral embolic protection devices in reducing ischemic central nervous system (CNS) injury during SAVR.
Design, Setting, And Participants: A randomized clinical trial of patients with calcific aortic stenosis undergoing SAVR at 18 North American centers between March 2015 and July 2016.
Background: Atrial fibrillation after cardiac surgery is associated with increased rates of death, complications, and hospitalizations. In patients with postoperative atrial fibrillation who are in stable condition, the best initial treatment strategy--heart-rate control or rhythm control--remains controversial.
Methods: Patients with new-onset postoperative atrial fibrillation were randomly assigned to undergo either rate control or rhythm control.