Publications by authors named "Karen L Morris"

Article Synopsis
  • * The bifactor model showed good overall fit for parent- and teacher-reported symptoms, with a strong general factor (high reliability) but less reliable specific factors for inattention and hyperactivity-impulsivity.
  • * Findings indicated that the general ADHD factor and specific inattentive factor were linked to impairment at home and school but did not relate to risky behavior in adolescents, highlighting implications for ADHD diagnostic criteria.
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  • The STEER program aimed to help teenage drivers with ADHD improve family dynamics and driving behavior compared to a standard driver education program.
  • In a study involving 172 teens, STEER led to less negative parenting and reported lower risky driving behaviors immediately after treatment and after six months.
  • However, by the twelve-month mark, differences in both parenting behaviors and risky driving were not significant, indicating that the long-term benefits of STEER may need further evaluation.
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Article Synopsis
  • Youth with ADHD tend to overestimate their driving abilities compared to actual performance, which may lead to risky driving behaviors.
  • A study involving 172 teenagers with ADHD used a driving simulator to assess their driving skills and self-assessment afterward.
  • Findings showed that stronger positive bias in self-ratings correlated with increased risky driving, highlighting the need for targeted prevention and intervention strategies for young drivers with ADHD.
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  • Patient preferences for ADHD treatments are crucial due to the variety of options and stakeholders involved, which include children, parents, and adults with ADHD.
  • *The review synthesized data from different preference assessment studies (like DCE, BWS, SGI) to determine which treatment aspects are commonly studied and most influential in decision-making.
  • *Results showed a predominance of studies focusing on parental preferences for medication over psychosocial treatments, highlighting mixed feelings among parents regarding stimulant use versus behavioral interventions.*
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Purpose: Our aims are to determine levels of circulating cellular and protein biomarkers in hepatocellular carcinoma (HCC) patients and to analyse any relationships with clinical parameters.

Methods: Fifty-four consenting patients were recruited. Circulating tumour cells (CTCs) were enumerated (by CellSearch) and characterised via filtration [by isolation by size of epithelial tumour cells (ISET)] with downstream immunohistochemistry (IHC).

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  • A study monitored parenting practices of teens with ADHD during driving to compare behaviors when the teens drove safely versus when they engaged in risky driving.* -
  • Overall, parents displayed low rates of positive parenting strategies, while criticism and anger were notably higher during risky driving situations.* -
  • The findings reveal a disconnect between observed parenting behaviors and recommended effective practices for teens with ADHD, indicating a need for more research on teaching driving to these teens.*
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We have investigated the effect of cloretazine (VNP40101M or Laromustine), a novel sulfonylhydrazine alkylating agent with significant antileukaemic activity, alone, or combined with cytarabine or daunorubicin, on the proliferation, viability and apoptosis of cell lines and acute myeloid leukaemia blast cells in vitro. Cloretazine alone induced a concentration-dependent inhibition of proliferation, reduction in cell viability and an increase in apoptosis in all samples tested. Combinations of cloretazine with varying concentrations of cytarabine or daunorubicin further enhanced these inhibitory effects, suggesting VNP40101M may have a role in combined low dose chemotherapy regimes especially in the elderly.

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