Publications by authors named "Karen L Hernandez"
Chronic intermittent hypoxia (CIH) inhibits plasma lipoprotein clearance and adipose lipoprotein lipase (LPL) activity in association with upregulation of an LPL inhibitor angiopoietin-like protein 4 (Angptl4). We hypothesize that CIH inhibits triglyceride (TG) uptake via Angptl4 and that an anti-Angptl4-neutralizing antibody would abolish the effects of CIH. Male C57BL/6J mice were exposed to four weeks of CIH or intermittent air (IA) while treated with Ab (30 mg/kg ip once a week).
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- Obstructive sleep apnea may lead to dyslipidemia and atherosclerosis by causing chronic intermittent hypoxia (CIH), which affects lipid metabolism by increasing levels of angiopoietin-like 4 (Angptl4) in adipose tissue.
- The study found that exposure to CIH in mice raised Angptl4 levels, inhibited lipoprotein lipase activity, and increased plasma triglycerides and atherosclerotic plaque size, effects that were reversed by a neutralizing antibody.
- Additionally, the role of hypoxia-inducible factor-1 (HIF-1) was significant, as its overexpression in adipose tissue resulted in similar metabolic issues, indicating that HIF-1 and Ang