Publications by authors named "Karen L Condon"
J Am Chem Soc
November 2006
Article Synopsis
- This study presents the X-ray crystal structures of the enzyme toluene/o-xylene monooxygenase hydroxylase (ToMOH) from Pseudomonas stutzeri OX1, both in its native form and when reconstituted with manganese(II), achieving resolutions of 1.85 and 2.20 A.
- The findings highlight the impact of reducing the dimetallic active site, leading to shifts in carboxylate and coordination environment that are critical for dioxygen binding and activation.
- Notably, the research identifies a significant rotamer shift in asparagine 202 that is conserved with methane monooxygenase hydroxylase (MMOH) and reveals previously unidentified hydrophobic pockets,
