Publications by authors named "Karen Hug"
Article Synopsis
- Many pathogenic bacteria possess plasmids that encode virulence factors, essential for their ability to infect and colonize hosts, but the regulation of these plasmids is not well understood.
- The study focuses on the type III secretion system (T3SS), crucial for human pathogenic bacteria, and reveals that its expression is influenced by the plasmid copy number, which increases with temperature, aiding in bacterial virulence.
- The chromosomal gene encoding polyadenylase PAP I is vital for controlling plasmid copy number, maintaining plasmid stability, and enhancing antibiotic resistance, highlighting its role in the regulation of virulence and antimicrobial resistance plasmids in bacteria.
, a vertically transmitted endosymbiont infecting many insects, spreads rapidly through uninfected populations by a mechanism known as cytoplasmic incompatibility (CI). In CI, a paternally delivered modification of the sperm leads to chromatin defects and lethality during and after the first mitosis of embryonic development in multiple species. However, whether CI-induced defects in later stage embryos are a consequence of the first division errors or caused by independent defects remains unresolved.
View Article and Find Full Text PDFAntibiotic-resistant bacteria are an emerging global health threat. New antimicrobials are urgently needed. The injectisome type III secretion system (T3SS), required by dozens of Gram-negative bacteria for virulence but largely absent from nonpathogenic bacteria, is an attractive antimicrobial target.
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