Publications by authors named "Karen Harrison-Phipps"

Article Synopsis
  • Stage IIIA-N2 non-small cell lung cancer (NSCLC) has low survival rates and lacks a standardized treatment, making patient management difficult.
  • This study analyzed 142 patients to assess overall survival (OS) and disease-free survival (DFS), finding the median OS to be 31 months, with no significant differences between treatment methods.
  • The results emphasize the need for personalized treatment plans and collaborative decision-making among healthcare professionals, with future research aimed at new therapies and multi-centre trials.
View Article and Find Full Text PDF

Thoracic surgery in the context of complex multimorbidity and clinical deterioration presents a unique set of challenges when balancing risk and benefit. Advances in anaesthesia, surgical technique, and imaging, have allowed for operative options for patients that were once deemed too high-risk. An effective proactive multi-disciplinary approach is essential for successful outcomes.

View Article and Find Full Text PDF

Background: Masaoka-Koga staging system remains the most frequently applied clinical staging system for thymic malignancy. However, the International Association for the Study of Lung Cancer (IASLC)/International Thymic Malignancy Interest Group (ITMIG) proposed a tumor-node-metastasis (TNM) staging system in 2014. This study aims to evaluate its impact on stage distribution, clinical implementation, and prognosis for thymomas.

View Article and Find Full Text PDF
Article Synopsis
  • The study evaluates the safety and feasibility of salvage thoracic surgery after immune checkpoint inhibitor treatment in patients with advanced non-small-cell lung cancer, focusing on nine cases involving pembrolizumab.
  • Results showed that surgery was performed effectively in patients with persistent disease or new lung nodules, with minimal access methods used in most procedures and no in-hospital deaths.
  • The findings suggest that despite challenges like post-treatment fibrosis, pulmonary resection is a viable option, but more research is needed to understand its effects on disease control and survival outcomes.
View Article and Find Full Text PDF

Objectives: Surgeons will face an increasing number of octogenarians with lung cancer potentially curable by surgery. The goal of this study was to evaluate short- and long-term outcomes after lung resection.

Methods: We performed a single-centre study of consecutive patients ≥80 years old, surgically treated for suspected lung cancer between 2009 and 2016.

View Article and Find Full Text PDF

Background: SARS-CoV-2 has challenged health service provision worldwide. This work evaluates safe surgical pathways and standard operating procedures implemented in the high volume, global city of London during the first wave of SARS-CoV-2 infection. We also assess the safety of minimally invasive surgery(MIS) for anatomical lung resection.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to determine if preoperative physical activity levels can predict the risk of complications after lung surgery.* -
  • Researchers tracked the daily steps of 90 patients before their surgery, ultimately analyzing data from 78 patients, and found that those with higher activity levels had significantly fewer complications compared to those with lower activity.* -
  • The findings suggest that being more physically active before surgery may lead to better postoperative outcomes, making it useful for assessing patient risk and improving recovery strategies.*
View Article and Find Full Text PDF

Objective: to validate the proposed N descriptor revision on a large cohort of patients and assess the impact of tumour location on the distribution pattern of lymph node metastases for patients with NSCLC.

Methods: This is a retrospective review of a consecutive series of patients who had anatomical lung resections. Systematic lymph node dissection was done for all patients.

View Article and Find Full Text PDF

Introduction: Respiratory failure has historically been the major cause of mortality after elective lung resections. With improved intubation using fiber-optic scopes, better preoperative respiratory risk assessment, more advanced anesthetic single lung ventilation, and minimally invasive surgical technique, this may have changed. Our objective was to assess the main causes of mortality over the past 10 years in patients undergoing elective lung surgery in a major UK center.

View Article and Find Full Text PDF

Objectives: The aim of this study was to report on the influence of tumor lymphovascular invasion on overall survival and in patients with resected non-small cell lung cancer and identify prognostic factors for survival.

Methods: This is a retrospective observational study of a consecutive series of patients who had surgical resection of non-small cell lung cancer in a single institution. The study covers a 3-year period.

View Article and Find Full Text PDF

Background: Chest drains are used routinely in thoracic surgery. Often a pursestring or mattress suture is used to facilitate closure of the defect on removal of the drain. This stitch can cause an unsightly scar, increase drain removal pain, and necessitate that the patient attend a community health care center to have this removed.

View Article and Find Full Text PDF

Background: Surgery remains the gold standard for patients with resectable nonsmall cell lung cancer. Current guidance identifies patients with poor pulmonary reserve to fall within a high-risk cohort. The aim of this study was to determine the clinical and quality of life outcomes of anatomical lung resection in patients deemed high risk based on pulmonary function measurements.

View Article and Find Full Text PDF

Fractures of the medial clavicle are rare injuries but are associated with significant morbidity and mortality. The current trend is shifting from conservative treatment to surgical intervention to reduce long-term sequelae. We present an isolated medial clavicular fracture associated with significant displacement and demonstrate excellent results after open reduction and internal fixation.

View Article and Find Full Text PDF

Objectives: Postoperative atrial fibrillation (POAF) increases morbidity, hospital stay and healthcare expenditure. This study aims to determine the perioperative factors correlating with POAF as well as to evaluate both treatment strategies and AF persistence beyond discharge.

Methods: The records of all patients undergoing anatomical lung resection over a 1-year period were retrospectively reviewed.

View Article and Find Full Text PDF

We report the case of a 39-year-old man presenting with an acute right-sided traumatic pneumothorax secondary to migration of a hypodermic needle fractured during intravenous drug use. We discuss the unusual passage of this foreign body from the left groin to the right ventricular wall and into the mediastinum, ultimately presenting with a right pneumothorax 1 year later.

View Article and Find Full Text PDF

A 75-year-old man previously underwent pneumonectomy for lung cancer. He subsequently had colorectal adenocarcinoma, and resection of metastases from his remaining lung was performed. Venovenous extracorporeal membrane oxygenation was used for perioperative respiratory support to facilitate intraoperative deflation of the remaining lung and optimization of the surgical field.

View Article and Find Full Text PDF
Article Synopsis
  • A structured review analyzed whether silver nitrate (SN) is effective for pleurodesis, identifying 42 papers and narrowing it down to 8 best evidence studies on the topic.* -
  • Studies showed that intrapleural SN injections achieved a high success rate (89-96%) for inducing pleurodesis in patients with malignant pleural effusion, matching the effectiveness of the commonly used talc slurry.* -
  • While SN demonstrated low recurrence rates in primary spontaneous pneumothorax treatment and had advantages over talc, long-term effectiveness still needs further research to be fully understood.*
View Article and Find Full Text PDF

Background To analyze if the number of open lung resections performed by trainees before starting video-assisted thoracic surgery (VATS) lobectomy training program has any impact on intraoperative and postoperative outcomes. Materials and Methods Retrospective analysis of 46 consecutive patients who underwent VATS lobectomies between December 2011 and September 2012 by two trainees (A.B.

View Article and Find Full Text PDF
Article Synopsis
  • * Researchers reviewed 107 patients over 6 years, finding that T/D led to full lung re-expansion in 86% of cases, with no postoperative deaths reported.
  • * Patients with culture-positive empyema faced longer hospital stays, extended pleural drainage, and higher complication rates, suggesting that this condition linked to worse overall outcomes.
View Article and Find Full Text PDF

Aims And Background: Several techniques have been proposed to perform a video-assisted thoracic lobectomy. We compared the results of a 3 versus 4-port procedure, analyzing intraoperative data, morbidity, and mortality.

Methods: Prospective analysis of 30 consecutive patients who underwent a 4-port approach video-assisted thoracic lobectomy (group A) and comparison with a historical series with 30 patients who had a 3-port video-assisted thoracic lobectomy (group B).

View Article and Find Full Text PDF

Pulmonary arteriovenous malformations are anomalous communications between arteries and veins of the pulmonary vasculature. Its incidence is rare. Pulmonary arteriovenous malformations can be asymptomatic or cause profound cardiovascular compromise and adverse neurological sequelae, as a result of right to left shunting of deoxygenated blood.

View Article and Find Full Text PDF
Article Synopsis
  • Inflammatory myofibroblastic tumors are uncommon, making up a tiny fraction of lung tumors, and are typically benign but can show malignant traits.
  • The primary treatment for these tumors is total surgical removal whenever they are detected.
  • A case report describes a significant pulmonary myofibroblastic tumor that necessitated a major surgical procedure to ensure complete removal.
View Article and Find Full Text PDF

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was 'Which stages of thymoma benefit from adjuvant chemotherapy post thymectomy?' Altogether more than 150 papers were found using the reported search, of which only eight represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated; these studies have mainly reported the survival and recurrence rates of post-thymectomy patients who received adjuvant radiotherapy or chemoradiotherapy, and adjuvant radiotherapy alone was only used in a small group of patients in these studies.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to assess the effectiveness of CoSeal® surgical sealant in reducing prolonged alveolar air leaks after lung surgeries.
  • It involved 121 patients who had an air leak during surgery, with half receiving standard care and the other half receiving standard care plus CoSeal®.
  • The results showed that while some patients initially stopped leaking, overall, those treated with CoSeal® experienced longer air leak durations, leading researchers to conclude that the sealant should not be routinely used.
View Article and Find Full Text PDF