Patterns of toxicity and factors influencing severity in acute adult trimipramine poisoning.

Aims: To analyze the clinical features of trimipramine poisoning, identify a minimal toxic dose, and the dose bearing a 50% risk of developing a moderate, severe or fatal outcome.

Methods: All acute adult trimipramine monointoxications reported by physicians to the Swiss Toxicological Information Centre between January 1992 and December 2009 were identified.

Results: Two hundred and thirty cases (26 confirmed and 204 probable) were analyzed, the mean age was 35.