Cell migration is crucial for organismal development and shapes organisms in health and disease. Although a lot of research has revealed the role of intracellular components and extracellular signaling in driving single and collective cell migration, the influence of physical properties of the tissue and the environment on migration phenomena in vivo remains less explored. In particular, the role of the extracellular matrix (ECM), which many cells move upon, is currently unclear.
View Article and Find Full Text PDFThe extracellular matrix is involved in facilitating morphogenesis during development in many contexts. Its role as a stable structure that supports, constrains and acts a substrate for migrating cells in developing tissues is well known and explored. However, recent studies that image fluorescently tagged matrix proteins in developing embryos and tissues, show more dynamic characteristics of matrices in diverse developmental contexts.
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