Survival in Cystic Fibrosis: Trends, Clinical Factors, and Prediction Models.

Cystic fibrosis (CF) is an autosomal recessive genetic disease that results in multiple medical complications, and ultimately decreased survival of affected patients. Due to multiple advances in early diagnosis, nutrition, and aggressive treatment of complications, survival of these patients has improved dramatically in the past 40 years. However, despite improved care, patients still die at a relatively young age, most commonly due to respiratory failure.

Longitudinal study of the effects of a high-fat diet on glucose regulation, hippocampal function, and cerebral insulin sensitivity in C57BL/6 mice.

Although the increasing rate of obesity has stimulated interest in the effects of diet composition on peripheral systems, comparatively little work has been done to examine effects upon the brain. A diet high in fat is one of many factors that can promote obesity, and previous research has shown that such a diet can produce learning and memory impairment in rodents. In the present study, C57BL/6 mice were placed on either a high-fat (45% kcal fat) or regular (5% kcal fat) diet, and examined at different points during the subsequent year.