Reduced attentional lapses in male rats following a combination treatment of low-dose D-serine and atomoxetine.

Background: Goal-directed attention involves the selective processing of behaviorally relevant sensory information. This selective processing is thought to be supported by glutamatergic and noradrenergic systems. Pharmacotherapies that simultaneously target these systems could therefore be effective treatments for impaired attention.

The use of reaction time distributions to study attention in male rats: the effects of atomoxetine and guanfacine.

Rationale: Norepinephrine (NE) is involved in the control of sustained attention. Studies of sustained attention in humans include measures of reaction time (RT) and RT variability (RTV). The present study tested the role of NE using components of the RT distribution in rats in a manner thought to be similar to human studies of RTV.

The effects of the β1 antagonist, metoprolol, on methamphetamine-induced changes in core temperature in the rat.

Methamphetamine (METH) results in hyperthermia or hypothermia depending on environmental conditions. Here we studied the role of the β1 adrenergic receptor in mediating METH's temperature effects. Core temperature measurements were made telemetrically over a 7.

Methamphetamine and core temperature in the rat: ambient temperature, dose, and the effect of a D2 receptor blocker.

Rationale: Methamphetamine (METH) induces hyperthermia in warm and hypothermia in cool environments. Our first goal was to further study the role of ambient temperature in METH's effect on core temperature in rats. Previously, these effects were primarily demonstrated in high doses; we extended this investigation to the low-dose range (1 mg/kg METH).

Relationship between methamphetamine-induced behavioral activation and hyperthermia.

Methamphetamine (METH) changes core temperature and induces behavioral activation. Behavioral activation is also known to change core temperature. The purpose of this report was to 1.

The effects of methamphetamine on core body temperature in the rat--part 2: an escalating regimen.

Rationale: Methamphetamine (METH) induces hyperthermia, which is diminished with chronic treatment in a dose-dependent manner. Our objective was to determine whether the temperature responses produced by a chronic, escalating-dose METH regimen and a chronic, 5.0 mg/kg dose regimen.

The effects of methamphetamine on core body temperature in the rat--part 1: chronic treatment and ambient temperature.

Rationale: Stimulants such as methamphetamine (METH) alter core temperature in a manner that is dependent on ambient temperature and that shows tolerance after chronic use. Our objectives were to (1) determine whether tolerance to METH-induced hyperthermia was a consequence of neurotoxicity to dopamine or serotonin and (2) determine the relationship between ambient temperature and chronic treatment on the METH-induced temperature response.

Materials And Methods: Rats were treated with 1.

Prenatal alcohol exposure causes attention deficits in male rats.

Children with fetal alcohol spectrum disorder (FASD) are often diagnosed with attention-deficit/ hyperactivity disorder (ADHD). These children show increases in reaction time (RT) variability and false alarms on choice reaction time (CRT) tasks. In this study, adult rats prenatally exposed to ethanol were trained to perform a CRT task.