In vitro and in vivo effects of chlorpyrifos and cypermethrin on blood cholinesterases in sheep.

The combination of the organophosphate (OP) chlorpyrifos (CPF) and the pyrethroid cypermethrin (CPM) is commonly marketed as pour-on formulations for the control of sheep lice, ked, and blowflies. CPF irreversibly inhibits acetylcholinesterases (AChE), while pyrethroids are not AChE inhibitors. However, combinations of pyrethroids with OPs showed a highly synergistic effect on AChE inhibition.

The herbicide glyphosate is a weak inhibitor of acetylcholinesterase in rats.

The current work evaluated the inhibitory potency of the herbicide glyphosate (GLP) on acetylcholinesterase (AChE) activity in male and female rat tissues. The AChE activity in brain was higher (p<0.05) than those observed in kidney (females: 2.

Rethinking Responsible Literature Searching using LibGuides.

Drawing from the Responsible Literature Searching project developed by the Health Sciences Library System-University of Pittsburgh, the Mayo Clinic Libraries utilized Springshare's LibGuides software to create an Effective Database Searching Guide for its diverse set of users. Library databases are organized under broad subject categories with overview information, links to help materials, and news on system updates. Additionally, the guide features a visual site map, searching best practices, a database comparison chart, responsible literature searching guidelines, classic evidence-based practice articles, and recommendations on when to contact a librarian for assistance.

Developing a transcultural patient care Web site.

The development of a transcultural Web site created by a multidisciplinary committee in a large medical center is described. The purpose of this Web site is to give direct patient caregivers immediate, around-the-clock access to various types of transcultural information that can serve as an aid in the provision of culturally competent care. This article outlines the steps to developing the Web site and provides a description of the types of informational resources available on it.