Differential estimation of verbal intelligence and performance intelligence scores from combined performance and demographic variables: the OPIE-3 verbal and performance algorithms.

Data from the WAIS-III standardization sample (The Psychological Corporation, 1997) was used to generate VIQ and PIQ estimation formulae using demographic variables and current WAIS-III subtest performances. The sample (n = 2450) was randomly divided into two groups; the first was used to develop formulas and the second to validate the regression equations. Age, education, ethnicity, gender, region of the country as well as Vocabulary, Matrix Reasoning, and Picture Completion subtests raw scores were used as predictor variables.

FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.

To investigate the consequences of mutant presenilin-1 (PS-1) expression under the control of the normal PS-1 gene, a gene-targeted mouse bearing the FAD mutation P264L was made. Gene-targeted models are distinct from transgenic models because the mutant gene is expressed at normal levels, in the absence of the wild-type protein. PS-1(P264L/P264L) mice had normal expression of PS-1 mRNA, but levels of the N- and C-terminal protein fragments of PS-1 were reduced while levels of the holoprotein were increased.