Publications by authors named "Karen Czeloth"
Article Synopsis
- Male fertility is impacted by paternal age, leading to increased germ cell mutations and potential congenital diseases in offspring.
- A study of 198 healthy men revealed that while semen and hormone profiles remain stable over time, sperm DNA stability declines after age 60, with significant methylation changes near genes related to neuronal development.
- The findings suggest a unique pattern of ageing in male germ cells, which may contribute to reduced fertility and health issues for children of older fathers.
Introduction: To date, several aspects of inflatable penile prosthesis (IPP) surgical procedure have been poorly studied.
Aim: The aim of this study was to review the evidence associated with IPP implantation and provide clinical recommendations on behalf of the European Society for Sexual Medicine (ESSM). Overall, 130 peer-reviewed studies and systematic reviews, which were published from 2007-2018 in the English language, were included.
The activation and function of c-Jun N-terminal kinases (JNKs) were investigated in primary microglia cultures from neonatal rat brain, which express all three JNK isoforms. Lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha), and thrombin preparations induced a rapid and lasting activation of JNKs in the cytoplasm. In the nucleus, the activation patterns were rather complex.
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