Publications by authors named "Karen Bamford"
Objectives: To analytically evaluate Ortho Clinical Diagnostics VITROS high-sensitivity cardiac troponin I (hs-cTnI) assay in specific matrices with comparison to other hs-cTn assays.
Methods: The limit of detection (LoD), imprecision, interference and stability testing for both serum and lithium heparin (Li-Hep) plasma for the VITROS hs-cTnI assay was determined. We performed Passing-Bablok regression analyses between sample types for the VITROS hs-cTnI assay and compared them to the Abbott ARCHITECT, Beckman Access and the Siemens ADVIA Centaur hs-cTnI assays.
Article Synopsis
- The study examines how different sample types (serum, lithium heparin plasma, and EDTA plasma) affect the measurement of high-sensitivity cardiac troponin I (hs-cTnI) using the Siemens ADVIA Centaur assay.
- It finds that there is strong agreement in troponin levels between serum and lithium heparin plasma, but lower levels in EDTA plasma, which indicates a need for further research on reference intervals for EDTA.
- Storage conditions impact results, with lithium heparin plasma showing a significant decrease in hs-cTnI concentrations when stored at room temperature, highlighting the importance of proper sample handling.