Publications by authors named "Karen Annis"
Article Synopsis
- Crisaborole ointment, a nonsteroidal topical treatment, was studied for its effectiveness and safety in treating stasis dermatitis (SD) in individuals aged 45 and older.
- In a phase 2a trial with 65 participants, those using crisaborole showed a greater reduction in SD symptoms compared to a vehicle group, as measured by both non-dermatologist and dermatologist assessments.
- Although results were promising, the study faced limitations such as a small sample size, short duration, and the in-person assessments being conducted by non-specialists.
Objective: Two studies evaluated efficacy and safety of tanezumab versus naproxen for treatment of knee or hip osteoarthritis (OA).
Methods: Randomized controlled studies [NCT00830063 (Study 1015, n=828) and NCT00863304 (Study 1018, n=840)] of subjects with hip or knee OA compared intravenous tanezumab (5 mg or 10 mg) to placebo and naproxen (500 mg twice daily). Coprimary outcomes were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain, WOMAC Physical Function (0-10 numerical rating scale), and patient's global assessment of OA at Week 16.
Hospitals often have limited ability to obtain primary clinical data from electronic health records to use in assessing quality and safety. We outline a new model that uses administrative data to gauge the safety of care at the hospital level. The model is based on a set of highly undesirable events (HUEs) defined using administrative data and can be customized to address the priorities and needs of different users.
View Article and Find Full Text PDFObjectives: We sought to determine whether angiotensin-converting enzyme inhibition (ACE-I) (i.e., quinapril) prevents transient ischemia (exertional and spontaneous) in patients with coronary artery disease (CAD).
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