Publications by authors named "Kareman Eljamal"
Objective: To develop a new mouse model of underactive bladder (UAB) caused by chronic bladder outlet obstruction (BOO).
Methods: BOO was created in 6-week-old male C57BL/6 mice using surgery to loosely place a silver jump ring around the bladder neck of each mouse. Micturition behavior (assessed with a metabolic cage) and cystometry were used to evaluate bladder function at 8 and 16 weeks after BOO.
Article Synopsis
- This study investigates how mirabegron, a drug used for bladder issues, relaxes smooth muscle in the bladder (detrusor) when combined with a β-adrenoceptor antagonist.
- Researchers examined human and pig bladder tissues to find out the mechanisms behind mirabegron's relaxant effects, using various inhibitors that target different signaling pathways.
- Results showed that mirabegron effectively reduces muscle contraction in both human and pig tissues, working through β-adrenoceptor/cAMP-dependent and independent pathways, indicating its potential utility in treating bladder conditions.