[The possibilities of surgical and combined treatment of patients with locally-disseminated renal cell carcinoma].

A comparative analysis of surgical and combined treatment of renal carcinoma in 84 patients has shown that preoperative embolization of the renal arteries failed to reduce blood loss and duration of operation, failed to increase recurrence-free period and 3 to 5 years survival of the patients. Specific features of combined interventions are described.

[Arterial embolization as palliation for inoperable renal carcinoma].

Embolization of the renal artery was performed as a palliative measure in 93 inoperable patients at the Center's Clinic in 1991-2000. Radio-endovascular intervention was indicated in cases of bleeding (19, 20.5%), case-history macrohematuria with high risk of relapse (54, 58%) and drug-controlled pain (20, 21.

[Influence of immunological parameters on the effectiveness of systemic and loco-regional immunotherapy in disseminated renal carcinoma].

Survival was assessed among patients with disseminated renal carcinoma from different prognostic groups as established by MSKCC protocol. Multivariate evaluation pointed to prognostic value of IL-6 (spontaneous and induced production), IL-8 (spontaneous and induced production),TNF-alpha (spontaneous production), IFN-gamma (induced production), TNK-cells (CD3+CD16+CD56+), and T-regulatory cells (CD4+CD25+Treg). It was demonstrated that additional criteria may be used to evaluate prognosis.

[Poorly differentiated prostate cancer may be associated with cytomegalovirus infection in prostatic tissue].

Polymerase chain-reaction procedure was used to test archival samples of prostate tissue from 90 cancer patients for cytomegalovirus infection detected in 46.7%. The median Gleason score and G-index (TNM classification) were significantly higher in CMV-positive patients (8 and 4, respectively) than those in CMV-negative ones (6 and 2, respectively).

[Positron emission tomography with 18-fluorine deoxyglucose in the diagnosis and assessment of prostate cancer].

Results of PET studies using 18-fluorine deoxyglucose (18-FDG) in patients with large-size masses (51) are discussed. Histologically-confirmed prostate cancer was diagnosed in 36 (70.5%), benign hyperplasia--12 (23.

[Role of hormonal profile in adjusting therapy for prostate cancer].

Changes in testosterone, prolactin and estradiol levels were evaluated vis-a-vis outcome and different patterns of androgen suppression--continuous androgen blockade or intermittent therapy--for prostate cancer patients. There was a significant difference between pre- (3.4 +/- 0.

[Capacities of complex ultrasound study in the diagnosis of prostate cancer].

Prostate cancer (PC) constitutes the bulk of male small pelvic abnormalities. The early diagnosis of PC is the most topical problem in oncourology. At present, ultrasound imaging is common in the diagnosis of prostatic diseases.

[Lymphoprostatic scintigraphy in regional lymphatic mapping in patients with prostate cancer].

The purpose of the investigation was to upgrade the diagnosis quality for metastatic lesion to the regional lymp nodes in prostate cancer. The results of the most widely used diagnostic techniques (computed tomography (CT), magnetic resonance Imaging, (MRI), radionuclide studies (RNS), and ultrasonography (USG)), which had been compared with those of histology of removed lymph nodes, were assessed. For this, 74 patients with prostate cancer were comprehensively examined and treated at the Central Research X-ray Radiolological Institute.

[Role of Ki-67, mutated gene-suppressor p53 and HER-2neu oncoprotein in the prognosis for the clinical course of bladder cancer].

A retrospective analysis included 63 patients with urothelial cancer. Untreated tumor tissue sampled in the course of primary surgery was examined by immunostaining procedure. After surgery, superficial tumors were treated with intravesical chemotherapy, invasive cancer--chemoradiotherapy.

[Prognosis of efficacy of organ-saving treatment of invasive bladder cancer].

It is suggested that Scr-index for radiation-induced apoptosis in leukocytes in vitro be determined prior to combined therapy of urinary bladder cancer in order to estimate its efficacy. It was identified by studying leukocytes of peripheral blood from patients in whony white blood cells DNA level decreased after exposure to 2 Gy and 3-hr incubation at 37 degrees C. Values over 1.

[Effectiveness of repeated systematic radiotherapy for generalized prostate cancer].

Examination of 127 patients with generalized prostate cancer established a low prophylactic effect of systematic treatment with strontium-39 chloride: it failed to alleviate pain in metastatic cancer, nor was it followed by longer mean survival. Repeat systematic radiotherapy is not indicated when palliative measures such as hormonal therapy, local radiotherapy and chemotherapy are still effective.

[Positron emission tomography in oncourology].

The authors present the results of the examination of 61 patients with genitourinary space-occupying lesions, using 18F- fluorodeoxyglucose positron emission tomography (PET) in whole body mode. In all cases the diagnosis was verified morphologically. The results demonstrated high diagnostic accuracy of PET, including possibility to determine the extent of oncourological cancer.

[Combined therapy for patients with invasive bladder cancer].

Organ preservation has been investigated inmuscle-invasivebladder cancer over the past years as an alternative to standard radical cystectomy. However, the morbidity of radical cystectomy and early reports of good results of radical transuretheral resection of bladder tumors (TURBT) have stimulated interest in combined treatment for muscle-invasive bladder cancer. Organ preservation requires a trimodal schedule, including transuretheral surgery, mega voltage radical external beam radiotherapy (EBRT) and adjuvant chemotherapy (ACT).

[Magnetic soft siloxane material for arterial embolization and hyperthermia of malignant tumors].

A newly developed polysiloxan material for arterial embolization of parenchymatous organs is described. This new agent can be used for distal-proximal embolization with following local hyperthermia. The preliminary results of clinical use are presented.

[Gene expression profiles of protein kinases and phosphatases obtained by hybridization with cDNA arrays: molecular portrait of human prostate carcinoma].

Hybridization with cDNA arrays was used to obtain expression profiles of 263 protein-tyrosine kinase (PTK), protein-tyrosine phosphatase (PTP), dual-specific phosphatase (DuSP), and other genes for the normal prostate tissue, primary prostate carcinomas (PC) of 84 patients, 7 xenografts, and 5 carcinoma cell lines. Analysis of 96 profiles revealed eight clusters of genes coexpressed in PC (coefficient of correlation r > 0.7).