Comparative Study on the Application of Mesenchymal Stromal Cells Combined with Tricalcium Phosphate Scaffold into Femoral Bone Defects.

This prospective study sought to evaluate the healing quality of implanted ultraporous β-tricalcium phosphate sown with expanded autologous mesenchymal stromal cells (MSCs) into femoral defects during revision hip arthroplasty. A total of 37 osseous defects in 37 patients were treated and evaluated concerning bone regeneration. Nineteen subjects received β-tricalcium phosphate graft material serving as a carrier of expanded autologous MSCs (the trial group A), nine subjects received β-tricalcium phosphate graft material only (the study group B) and nine subjects received cancellous allografts only (the control group C).

Utilizing Autologous Multipotent Mesenchymal Stromal Cells and β-Tricalcium Phosphate Scaffold in Human Bone Defects: A Prospective, Controlled Feasibility Trial.

The purpose of this prospective controlled study was to compare healing quality following the implantation of ultraporous β-tricalcium phosphate, containing either expanded autologous mesenchymal stromal cells (trial group, 9 patients) or β-tricalcium phosphate alone (control group, 9 patients), into femoral defects during revision total hip arthroplasty. Both groups were assessed using the Harris Hip Score, radiography, and DEXA scanning at 6 weeks and 3, 6, and 12 months postoperatively. A significant difference in the bone defect healing was observed between both groups of patients (P < 0.

Osteointegration of an uncemented modular revision stem implanted during revision hip surgery.

Background: Though mid-term survival rates of over 95% in several series have been published, there is still a paucity of related literature regarding the role of vertical stem instability in the osteointegration of fluted tapered stems. This paper presents a comprehensive and prospective assessment on short-term experiences with uncemented modular femoral stem in the treatment of defective femur during revision surgery of total hip replacement.

Materials And Methods: Clinical and radiological monitoring of 20 consecutive patients with implanted tapered fluted revision stem (Lima Corporate, Udine, Italy) was of 27 months in average (20-35 months).

Histological assessment of tissue from large human bone defects repaired with β-tricalcium phosphate.

This report describes the histological characteristics of large human bone defects that were implanted with β-tricalcium phosphate (β-TCP). Samples were obtained longer after the primary operation than in the earlier studies. We assessed a total of nine biopsies taken 33-208 weeks after implantation.

Comparative outcomes of total knee arthroplasty on physically active and passive patients.

The physical activity of the population is decreasing due to an increase in sedentary lifestyles. The aim of the study was to analyze midterm results of total knee arthroplasty according to the lifelong physical activity of the patients. We evaluated 37 patients (23 women, 14 men), with age average 70.

Charcot arthropathy of the knee. A case-based review.

The diagnosis of Charcot arthropathy in the knee is rare. However, there is an increasing number of diabetic patients, and they are living longer due to improvements in treatment. Because neuropathic arthropathy is a late effect of peripheral neuropathy, we can expect an increasing incidence of neuropathic arthropathy.

In vivo behaviour of low-temperature calcium-deficient hydroxyapatite: comparison with deproteinised bovine bone.

This study aims to evaluate in detail the biological osteoconductive properties of the low-temperature synthetic porous calcium-deficient hydroxyapatite and to compare it with the biological apatite. Bone reactions to granules of similar sizes of the low-temperature hydroxyapatite and commercially available non-sintered deproteinized bovine bone were compared. Two different temperatures were used to fabricate two batches of newly developed porous hydroxyapatite with different carbonate groups content and specific surface area.

Behavior of bioactive glass-ceramic implanted into long bone defects: a scintigraphic study.

The purpose of the study was to assess the long-term behavior and incorporation of the bioactive oxyhydroxyapatite glass-ceramic used to fill defects of long bones after curettage of bone cysts in 17 patients. The method of evaluation was a three-phase bone scintigraphy combined with radiographic and clinical evaluation. At a mean follow-up of 7 years, the glass-ceramic material had been completely incorporated.

Behaviour of nonresorbable bioactive glass-ceramic implanted into long bone defects: comparison with cancellous allografts.

Introduction: The goal of this retrospective study was to compare the long-term results after implantation of the nonresorbable glass-ceramic material and transplantation of the cancellous allografts into the defects of long bones.

Method: The bone cysts were excochleated and filled using granules of glass-ceramic material or cancellous allografts. Clinical, radiographic and scintigraphic examinations of 30 patients were carried out 2-14 years after their surgery.

Methotrexate released in vitro from bone cement inhibits human stem cell proliferation in S/G2 phase.

Methotrexate (MTX) released from bone cement showed a useful local effect in animal models of bone tumours. However, local toxic reactions such as impaired wound healing were observed in areas surrounding the MTX-loaded implant. Therefore, we hypothesised that MTX released from bone cement would have harmful effects on human mesenchymal stem cells (MSC)-one of the basic components of bone marrow and tissue reparatory processes.

Secondary stability assessment of titanium implants with an alkali-etched surface: a resonance frequency analysis study in beagle dogs.

Purpose: This study was carried out to quantify the effect of an alkali-modified surface on implant stability during healing using an animal model.

Materials And Methods: A total of 24 screw-shaped, self-tapping, commercially pure titanium dental implants, divided into a test group (implants with an alkali-modified surface or "biosurface") and a control group (implants with a turned, machined surface) were inserted without pretapping in the tibiae of 3 beagle dogs. The resonance frequency analysis method was used to measure the implant stability quotient (ISQ) 0, 1, 3, 9, and 12 weeks after implantation.

Grade-III slipped capital femoral epiphysis with unstability: a report of three cases.

We reviewed the cases of three patients with an unstable grade-III slipped capital femoral epiphysis treated between 2001 and 2003. Clinical records and imaging studies were reviewed for patient's history, anatomic features of the slip, definitive treatment and clinical outcome. The duration of the follow-up ranged from twenty-four to fourty-eight months.