Publications by authors named "Karanvir Singh Matharoo"
The Effectiveness of SARS-CoV-2 Vaccination in Preventing Severe Illness and Death - Real-world Data from a Cohort of Patients Hospitalized with COVID-19.
Indian J Community Med
December 2022
Background: While long-term studies on the correlates of protection, vaccine effectiveness, and enhanced surveillance are awaited for SARS-CoV-2 vaccine, studies on breakthrough infections help understand the nature and course of this illness among vaccinated individuals and guide in public health preparedness. This study aims to compare the differences in the hospitalization outcomes SARS-CoV-2 infection of fully vaccinated individuals with with those of unvaccinated and partially vaccinated individuals.
Materials And Methods: Single institution observational cohort study.
Background: Hypoxia in patients with COVID-19 is one of the strongest predictors of mortality. Silent hypoxia is characterised by the presence of hypoxia without dyspnoea. Silent hypoxia has been shown to affect the outcome in previous studies.
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- - The study examined 2,080 COVID-19 patients during India’s second wave (April-June 2021), finding a 19.5% fatality rate and revealing that older patients (over 45) had significantly higher death odds compared to younger patients (18-44).
- - Vaccination significantly decreased the risk of death by 40%, and patients exhibiting signs of hyperinflammation had higher mortality rates.
- - The findings suggest that improving vaccination rates and ensuring early hospital admission during the inflammatory phase can lead to better patient outcomes with COVID-19.