Publications by authors named "Karanveer Kaushal"
Bioinform Biol Insights
July 2023
Article Synopsis
- NSP16 is a crucial protein in SARS-CoV-2 that helps the virus enter host cells and replicates by methylating viral RNA using S-adenosyl methionine (SAM).
- Researchers employed in silico drug repurposing techniques to identify FDA-approved drugs that could effectively inhibit the SAM binding site on NSP16, discovering three potential candidates: framycetin, paromomycin, and amikacin.
- Molecular dynamics simulations indicated that these drugs may serve as promising treatments for SARS-CoV-2 by hindering the virus's ability to evade the host immune system.
