Publications by authors named "Karanpreet Singh"
Article Synopsis
- The study analyzes demographic differences, comorbidities, and hospital outcomes in gastric cancer inpatients, focusing on sex differences.
- The research included 22,415 adult patients with gastric cancer, revealing a higher prevalence of conditions like metastasis and complicated diabetes among male patients.
- Findings indicate that females aged 50-59 have a significantly higher risk of in-hospital mortality, while Black males face increased mortality risks compared to White males, highlighting ongoing challenges in gastric cancer management despite advancements in care.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFAligned extracellular matrix fibers enable fibroblasts to undergo myofibroblastic activation and achieve elongated shapes. Activated fibroblasts are able to contract, perpetuating the alignment of these fibers. This poorly understood feedback process is critical in chronic fibrosis conditions, including cancer.
View Article and Find Full Text PDFMetformin has been shown to alter cell adhesion protein expression, which is thought to play a role in its observed antitumor properties. We found that metformin treatment down-regulated integrin β1 concomitant with the loss of inositol polyphosphate multikinase (IPMK) in murine myocytes, adipocytes, and hepatocytes. To determine if IPMK was upstream of integrin β1 expression, we examined IPMK mouse embryonic fibroblast cells and found that integrins β1 and β3 gene expression was reduced by half, relative to wild-type cells, whereas focal adhesion kinase (FAK) activity and Rho/Rac/Cdc42 protein levels were increased, resulting in migration defects.
View Article and Find Full Text PDF