Combined creatinine velocity and nadir creatinine: A reliable predictor of renal outcome in neonatally diagnosed posterior urethral valves.

Introduction: Nadir creatinine (lowest creatinine during the first year following diagnosis) is a recognised indicator of future chronic renal impairment (CRI) in posterior urethral valve (PUV) patients. We recently described "creatinine velocity" (Cvel), the rate of change of creatinine following initial bladder drainage, as a new early predictor of CRI in neonatally diagnosed PUV. Rising Cvel (>3 μmol/L/day) is associated with increased risk of CRI.

Mitrofanoff for valve bladder syndrome: effect on urinary tract and renal function.

Purpose: Despite early diagnosis and valve ablation, progressive renal impairment develops in a significant proportion of boys born with posterior urethral valves. Bladder dysfunction is thought to have an important role in the etiology of this renal deterioration. We report the outcome of treating bladder dysfunction with clean intermittent catheterization and overnight drainage via a Mitrofanoff appendicovesicostomy with respect to upper tract imaging, urodynamic findings and renal function.

Posterior urethral valves: creatinine velocity, a new early predictor of renal insufficiency.

Aim: Antenatal screening has led to early detection of posterior urethral valves (PUV). However, despite early intervention, a proportion of children will develop chronic renal insufficiency. We studied the trend of serum creatinine following urinary tract decompression during the neonatal period in infants as a possible predictor of chronic renal insufficiency.

Endoscopic placement of double-J ureteric stents in children as a treatment for primary obstructive megaureter.

Aim: To determine the efficacy and potential complications of double-J ureteric stents in the treatment of persistent or progressive primary obstructive megaureter in pediatric patients within our institution.

Materials And Methods: A retrospective case-note review of all patients with double-J ureteric stents, between 1997 and 2004, was performed. In all, 38 stents were inserted in 31 patients aged between 2 months and 15 years of age.

Paediatric priapism--treatment conundrum.

Priapism is a rare condition in childhood. The majority of reported cases are boys with sickle cell disease, in whom nonoperative management may be successful when patients present early. We report a 14-year-old boy with sickle cell disease who presented with priapism of 72-h duration and was successfully treated by bilateral saphenocorporal shunts.

Neonatal prostatic rhabdomyosarcoma.

Rhabdomyosarcoma is one of the commonest soft tissue sarcomas of childhood, but neonatal presentation is extremely rare. This limited experience means there are no clear treatment guidelines in this age group. The authors report a boy with recurrent attacks of hematuria commencing in the neonatal period, which were shown to be from a prostatic rhabdomyosarcoma.

Bilateral multifocal renal oncocytoma.

Renal oncocytoma is a rare benign tumor. Bilateral and multifocal renal oncocytoma has rarely been described in childhood. We report a 12-year-old girl who presented with massive left renomegaly and who was found to have bilateral cystic kidneys.