Publications by authors named "Karan Joshua Abraham"
Survival of motor neuron (SMN) functions in diverse biological pathways via recognition of symmetric dimethylarginine (Rme2s) on proteins by its Tudor domain, and deficiency of SMN leads to spinal muscular atrophy. Here we report a potent and selective antagonist with a 4-iminopyridine scaffold targeting the Tudor domain of SMN. Our structural and mutagenesis studies indicate that both the aromatic ring and imino groups of compound 1 contribute to its selective binding to SMN.
View Article and Find Full Text PDFGermline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast and ovarian cancer risk. Given that tumors with these mutations have elevated genomic instability, they exhibit relative vulnerability to certain chemotherapies and targeted treatments based on poly (ADP-ribose) polymerase (PARP) inhibition. However, the molecular mechanisms that influence cancer risk and therapeutic benefit or resistance remain only partially understood.
View Article and Find Full Text PDFObjective: The objective is to determine if suspected concussions in elite football are medically assessed according to the International Conferences on Concussion in Sport consensus statement recommendations.
Setting: Men's Union of European Football Association (UEFA) Football Championship.
Participants: All professional football players in the UEFA 2016 Championship Tournament.
Karan ("Josh") Abraham is a physician-scientist trainee in the University of Toronto MD-PhD program. He is a Vanier Scholar, Ruggle's Innovation Award winner, Adel S. Sedra Distinguished Graduate Award recipient, and is currently president of the Clinician-Investigator Trainee Association of Canada (CITAC).
View Article and Find Full Text PDFMessage from the President: Optimism for the Future The Clinician-Investigator Trainee Association of Canada (CITAC) was established in 2006 to address issues relevant to Canadian trainees seeking dual training in medicine and research. As clinician-investigator (CI) trainees, we comprise but a fraction (less than 5%) of all medical trainees. Our 'bilingual' careers render our individual paths less straightforward and more challenging.
View Article and Find Full Text PDFArticle Synopsis
- Amyloids are significant in both human diseases and naturally occurring processes, showing potential for interaction and mutual influence in their aggregation.
- A specific example includes the interaction between amyloid β peptide (Aβ), linked to Alzheimer’s disease, and somatostatin (SST), which is stored as amyloid before being released during neuronal activity.
- The review explores existing literature on Aβ and SST, their individual biogenesis and interactions, and speculates on their encounters in the brain, emphasizing SST's relevance to Alzheimer's pathobiology while suggesting that interactions among various amyloids could be crucial for understanding dementias and related disorders.