Publications by authors named "Karam Asad"
The multiaddition chemistry of azafullerene C N has been scarcely explored, and the isolation of pure bisadducts is in its infancy. Encouraged by the recent regioselective synthesis of the inherently chiral equatorial bisadduct of C N, we focused on the isolation of the first trans-4 bisadduct in a simple two-step approach. The first regioselective synthesis of the trans-4 bisadduct of C N by using cyclo-[2]-dodecylmalonate as a tether is now reported.
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- The study investigates how tetragonal prismatic nanocapsules selectively separate fullerenes and endohedral metallofullerenes, highlighting the need to understand their recognition and binding processes.
- A combination of H-H exchange spectroscopy NMR, long time-scale Molecular Dynamics (MD), and accelerated Molecular Dynamics (aMD) simulations was developed to analyze the binding and unbinding pathways of fullerenes in detail.
- Findings reveal that the receptor capsule mimics biomolecular recognition seen in proteins and introduces the first exploration of bis-aza[60]fullerene encapsulation, providing insights into the dynamics and stability of the encapsulated structure.
Bisazafullerene (C N) has been functionalized under aerobic conditions with cyclo-[2]-octylmalonate through a Mannich-type reaction, furnishing the corresponding monoadduct. A regioselective tether-directed Bingel cyclopropanation reaction was then carried out on the azafullerene core to yield a single bisadduct. Spectroscopic analysis of the formed bisadduct showed it to have a C symmetrical structure, making it inherently chiral.
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