Matrix metalloproteinase-9 (mmp-9) in children with dengue virus infection.

The purpose of this study was to investigate the role of matrix metalloproteinase-9 (MMP-9) in the pathogenesis of vascular leakage in patients with dengue virus infection. Serum samples from 24 children with serologically confirmed dengue virus infection (dengue fever [DF], 16; dengue hemorrhagic fever [DHF], 8; age, 9.5+/-2.

The role of vascular endothelial growth factor leading to vascular leakage in children with dengue virus infection.

Unlabelled: Increased vascular permeability is the main aetiology for hypovolaemic shock and circulatory failure in dengue haemorrhagic fever (DHF).

Aim: To investigate the role of vascular endothelial growth factor (VEGF) in the pathogenesis of DHF.

Methods: Serum samples from 41 patients [15 dengue fever (DF), 26 DHF] with serologically confirmed dengue virus infection during the febrile, toxic, convalescent stages and at follow-up were analysed for VEGF.