[A comparative study of the potentials of a cytological method, the progesterone test and echography in the early detection of endometrial carcinoma in women in the postmenopause].

An attempt was made to examine and compare the abilities of the cytological method, the progesterone test and the uterus sonography for early finding and screening of endometrial cancer in postmenopausal women. There were studied three groups of patients, each group of them consisted of 900 women, for the period of 10 years. The uterus sonography and progesterone test showed the best results.

[The early detection and screening of endometrial carcinoma by the progesterone test and uterine sonography].

An attempt was made to examine the efficiency of the progesterone test and uterus sonography for ten-years period. The progesterone test was used for 621 patients, most of them from the University Obstetrics and Gynaecological Hospital in the town of Varna. Department of Obstetrics and Gynaecology as well as at the National Oncological Centre, Gynaecological Clinic--Sofia during the last few years.

[The posttherapy survival of patients with invasive cancer of the vulva].

The treatment results and five-years survival are studied in 157 patients with invasive vulvar cancer treated for the period of 1979-1988 in Gynaecological Clinic of the National Oncological Center Institute in Sofia. The general five years survival is 59.2%.

[The surgical treatment and results in patients with leukoplakia vulvae].

For period from 1976 to 1988 in the Clinic of Gynecology were treated 78 patients (women--31-74 years old) with leukoplakia vulvae. 61 patients (77.2%) were subjected to classical simple vulvectomy.

[The conservative treatment of carcinoma in situ of the cervix uteri by the local application of 5-fluorouracil].

Local treatment with 5% of 5-Fluorouracil (5-Fu) in the form of globules was carried out on 37 patients with carcinoma in situ of the uterine cervix, established histologically, as the application was performed once daily for a period of 14-20 days. There was a complete correlation between the cytological investigation after the conservative treatment and the histological examination of the operative material from the conization, which was made within 1-2 weeks after local application of 5-Fu. It could be possible to use cytology for objective determination of the therapeutic effect as well as a possible usage of colposcopic-directed biopsy.

[Organ-preserving operations on patients with microinvasive carcinoma of the cervix uteri].

Organ-preserving operative treatment was performed on 29 women with microinvasive operative microinvasive carcinoma of the uterine cervix at lal clinical stages. After conization of the uterine cervix the patients were observed actively by cytology, colposcopy and, when it was necessary, a colposcopic-directed biopsy was made during a period of 3-98 as there was no relapse of the disease in neither case. The authors think that it is possible to perform conization in young women with minimal stromal invasion up to 1000 microns as their reproductive function is preserved without any risk for occurrence of a relapse.

[The diagnosis, management and treatment results in patients with carcinoma in situ of the cervix uteri].

The authors analysed the results of 225 women with carcinoma of the uterine cervix, treated at the gynecological clinic of the National Oncological Center for a 10-year period. The mean age was 36.7 years.

[Metastasis in patients with uterine tube carcinoma].

Lymphogenic, hematogenic and implanted metastases in 10 women with carcinoma of the uterine tube, treated at the gynecological clinic of the National Oncological Center for the period of 1977-1988, were described. The patients were of the age of 44 to 65 years. Lymphogenic metastases were discovered in: iliac lymph nodes (l.

[Malignant melanoma of the vulva and vagina (a report of 4 cases and review of the literature)].

Three women with malignant melanocarcinoma of the vulva and one woman with malignant melanocarcinoma of the vagina were treated at the gynecological clinic of the National Oncological Center for the period of 1983-1988. The mean age of the patients was 52 years. In all patients melanocarcinoma was IV-V degree according to Crark as in 2 women it was pigmented, but in 2 women--achromatic.

[The reproductive function in women with preinvasive and microinvasive carcinomas of the cervix uteri treated by conization].

An inquiry was carried out on 46 women with preclinical carcinoma of the uterine cervix, treated with conization at the gynecological clinic of the National Oncological Center. Women were at the age of 22 to 38 years. Conization was made on 8 women on account of microinvasive carcinoma with invasion up to 1000 mkm, but on 38 women--on account of carcinoma of 0 degree.

[Current concepts in the prevention and early diagnosis of endometrial cancer].

The quick increase of morbidity, caused by the endometrial carcinoma in our country during recent 15 years from 5,2 to 16,5 per 100,000 raises acutely the question about effective primary and secondary prophylaxis. Having in mind the role of hyperestrogenemia in the etiology of endometrial carcinoma and the fact that the results from its treatment are determined basically by the degree of distribution of the tumor, the authors think that it is necessary fight for rational feeding, timely treatment of the disease with hyperestrogenemia and prophylactic therapy with gestagens. Cytologic examination of aspirate, obtained from the uterine cavity, is proposed as screening method for women of the risk groups.