Publications by authors named "Karabulut D"

Background: There is limited information on the immediate effects of whole-body vibration (WBV) on the upper limb. This study aims to determine the immediate effects of WBV on reaction speed and proprioception in young adult students' upper extremities.

Methods: In total, 62 students participated in the study.

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  • This study evaluated the 6-min pegboard and ring test (6PBRT) as a tool to assess upper extremity functional capacity in children with Duchenne muscular dystrophy (DMD).
  • The test demonstrated excellent reliability with a very strong correlation between repeated measures, indicating it is a consistent assessment method.
  • Additionally, the 6PBRT scores showed meaningful correlations with handgrip strength, muscle strength, and overall quality of life, confirming its validity in measuring upper extremity function in DMD patients.
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Neuroinflammation can be triggered by a high-fat/high-fructose diet (HFFD), and CD36 may be an underlying mechanism. Lauric acid (LA), the major fatty acid in coconut oil, and resveratrol, the plant-based polyphenolic compound, may exert anti-inflammatory effects. Therefore, this study investigated the possible effects of LA and resveratrol on diet-induced neuroinflammation and CD36.

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Cardiomyopathy, which is shortly defined as a disease of the myocardium, has a broad definition that includes many different diagnoses. Recent advances in cardiac imaging techniques, including basic and advanced echocardiography, computed tomography, nuclear medicine, and cardiac magnetic resonance, allow for a more accurate evaluation of volumes and thickness of cardiac chambers, systolic and diastolic function of the ventricules, and tissue structure. Multimodality imaging often provides the first clinical suspicion for specific etiologies, especially when the medical and family history is unclear, by identification of red flags of underlying systemic diseases.

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Purpose: To evaluate the prognostic effects of apparent diffusion coefficient (ADC) values, qualitative MRI findings, and XRCC1 polymorphism in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods: Between January 2019 and December 2021, 41 PDAC patients (23 males; 66.6 ± 8.

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  • The study aimed to examine the protective effects of Thymoquinone (THQ) against testicular damage induced by Methotrexate (MTX) in rats.
  • The experiment involved five groups and included sperm analysis, histopathology, and biochemical tests to assess the impact on testicular health.
  • Results showed that THQ significantly improved sperm quality and testicular function parameters, indicating its potential role in mitigating infertility caused by chemotherapy.
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Aims: We aimed to determine the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is) and to identify clinical factors associated with their use in patients with heart failure (HF) in a real-life setting.

Methods: Real-world data on Empagliflozin and Dapagliflozin use in patients with HEART failure: The RED-HEART study is a multicentre, cross-sectional and observational study that included HF patients in the outpatient setting regardless of ejection fraction from 19 cardiology centres between August 2023 and December 2023.

Results: The study population consisted of 1923 patients with HF, predominantly men (61.

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: Transverse maxillary deficiency is an important maxillary anomaly that is very common in society and remains current in orthodontics. The maxillary expansion has been used in treatment for a long time. While maxillary expansion can be performed with rapid maxillary expansion in young adults, it is performed with surgically assisted rapid maxillary expansion (SARME) in individuals who have reached skeletal maturity.

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Background: Despite advancements in percutaneous and surgical revascularization techniques, nearly 20% of patients who undergo myocardial revascularization need repeat revascularization. Recently, identified as a prognostication factor for adverse cardiovascular events, the uric acid/albumin ratio (UAR) serves as a new marker for assessing inflammation and oxidative stress. Our objective was to investigate the association between UAR levels and repeat revascularization in young patients with acute coronary syndrome (ACS).

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  • Gelsolin (GSN) has two forms: plasma (pGSN) and cytosolic (cGSN), which are linked to various diseases.
  • The study examined how chronic sustained hypoxia (CSH) impacts GSN levels and HIF-1 in rats, alongside measuring apoptosis and redox status.
  • Findings revealed that HIF-1α significantly increased in severe hypoxia, while pGSN decreased in both plasma and tissue, and cGSN levels increased in lung tissue, indicating a potential protective mechanism against cell damage.
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  • Cisplatin is an anticancer drug that causes liver damage, and this study investigates the protective effects of Myricetin, a flavonoid, against that damage.
  • The experiment involved 32 male rats divided into four groups to assess the histological changes and biochemical markers related to liver health.
  • Results showed that Myricetin improved liver tissue structure and reduced inflammatory markers and liver enzyme levels associated with Cisplatin toxicity, suggesting it may help mitigate the drug's harmful effects.
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Objective: Heart failure is a leading cause of death and the most common diagnosis leading to hospitalization. Its awareness is lower than that of other cardiovascular diseases, both in the general population and among patients with heart failure (HF). This study aimed to establish the current level of knowledge about HF in patients with HF with reduced ejection fraction (HFrEF) and mildly reduced ejection fraction (HFmrEF) in Türkiye.

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Objectives: The study aimed to examine the histopathological and biomechanical effects of papaverine administered intraperitoneally and locally on Achilles tendon healing in a rat model.

Materials And Methods: Forty-eight adult male Sprague-Dawley rats (range, 300 to 400 g) were used in this study conducted between October and November 2022. The rats were divided into three groups, with each group further subdivided into two for sacrifice on either the 15 (early period) or 30 (late period) day after surgery.

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Objective: Predictive value of systemic immune-inflammation index (SII) has been shown in clinical outcomes and complexity of coronary artery disease, acute coronary syndrome, and heart failure. We sight to evaluate value of SII in patients with lower extremity arterial disease (LEAD).

Methods: A total of 271 patients diagnosed with LEAD were included to our study.

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  • - This study investigates the cardiotoxic effects of methotrexate (MTX), a chemotherapy drug, and the potential protective role of vitamin B12 in mitigating this toxicity in rats.
  • - Rats were divided into four groups: a control group, a vitamin B12 group, an MTX group, and a combined MTX and vitamin B12 group, with various biomarkers and tissue expressions evaluated to assess heart health.
  • - The results showed MTX caused significant negative changes in heart-related factors and that vitamin B12 effectively normalized these changes, emphasizing the importance of vitamin B12 supplementation during MTX treatment.
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The research groups in computer vision, graphics, and machine learning have dedicated a substantial amount of attention to the areas of 3D object reconstruction, augmentation, and registration. Deep learning is the predominant method used in artificial intelligence for addressing computer vision challenges. However, deep learning on three-dimensional data presents distinct obstacles and is now in its nascent phase.

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Purpose: We aimed to explore the performance of diffusion-tensor imaging (DTI) and apparent diffusion coefficient (ADC) parameters in evaluating disease-free survival (DFS) and overall survival (OS) in patients with invasive breast cancer.

Material And Methods: A total of 49 women with invasive breast cancer who were diagnosed between 2017 and 2022 were included. All patients underwent breast magnetic resonance imaging (MRI) with DTI and diffusion-weighted imaging (DWI) features, with examiners blinded to the clinical data.

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Objective: Uric acid to albumin ratio (UAR) reflects inflammatory activity and its predictive value has been shown in various diseases. In this study, we sought to evaluate the value of uric acid to albumin ratio in patients with peripheral arterial disease (PAD).

Patients And Methods: Two hundred forty-three PAD patients were divided into TransAtlantic Inter-Society Consensus-II (TASC-II) A-B and TASC-II C-D groups, according to their TASC-II classification.

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  • - Quinoa is a nutritious, gluten-free pseudocereal, and this study examined its effects on glucose homeostasis in rats fed a cafeteria diet that led to obesity.
  • - Rats were divided into four diet groups: control chow, quinoa, cafeteria diet, and a combination of quinoa and cafeteria diet, with varied impacts on body weight, insulin levels, and liver health observed among groups after 15 weeks.
  • - The study concluded that quinoa may help prevent obesity and related metabolic issues like glucose intolerance and liver resistance, suggesting its potential as a functional food.
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This study aimed to investigate the protective effect of melatonin against the acute toxicity of cisplatin in ocular tissues. The eyes of 40 rats were divided into 4 groups: Control group (10 rats), Melatonin (Mel) group (10 rats), Cisplatin (Cis) group (10 rats), Melatonin (Mel) + Cisplatin (Cis) group (10 rats). Retina, cornea, and ciliary body tissues were examined after hematoxylin-eosin staining of sections obtained from the eyes and were scored for disorganization and degeneration.

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Objectives: Insulin resistance (IR) is associated with an increased risk of adverse cardiovascular outcomes. The triglyceride-glucose index (TyG index) is a reliable marker of IR. No study has examined the impact of the TyG index on major adverse cardiac and cerebrovascular events (MACCEs) in RTRs.

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Background: Gastric teratoma (GT) occurs as a rule in infancy and is an extremely unusual gastric tumor in adult patients.

Case Presentation: In this paper, we present the clinical and imaging findings of a 56-year-old female patient with a GT. The patient's main symptoms were increasing abdominal discomfort and pain.

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  • * The study involved administering NP and TQ to different rat groups to evaluate the effects on brain health and behavior, using various tests and tissue evaluations.
  • * Results indicated that NP caused significant brain damage and behavioral issues, but TQ treatment improved these conditions by reducing neuron degeneration and oxidative stress markers.
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Background: Hypertrophic cardiomyopathy is a common genetic heart disease and up to 40%-60% of patients have mutations in cardiac sarcomere protein genes. This genetic diagnosis study aimed to detect pathogenic or likely pathogenic sarcomeric and non-sarcomeric gene mutations and to confirm a final molecular diagnosis in patients diagnosed with hypertrophic cardiomyopathy.

Methods: A total of 392 patients with hypertrophic cardiomyopathy were included in this nationwide multicenter study conducted at 23 centers across Türkiye.

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Background: Contrast induced nephropathy (CIN) is one of the feared complications of contrast medium-using procedures. Present study was conducted in order to evaluate the value of systemic inflammatory-response index (SIRI) for development of CIN among patients who underwent primary percutaneous intervention.

Methods: Six hundred seventy-six patients with the diagnosis of ST elevation myocardial infarction were included.

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