Evaluation of Post-thrombolytic Events to Determine Appropriate ICU Monitoring Duration for Patients with Ischemic Stroke.

Background: Standard treatment for eligible patients presenting with acute ischemic stroke (AIS) is thrombolysis with tissue plasminogen activators alteplase or tenecteplase. Current guidelines recommend monitoring patients in an intensive care unit (ICU) for 24 h after thrombolytic therapy. However, recent studies have questioned the need for prolonged ICU monitoring.

Pre-pregnancy weight loss associations with prenatal and postpartum mental health conditions: A retrospective cohort study.

Background: Obesity is a risk factor for adverse outcomes during and following pregnancy. Most women are advised to lose weight prior to becoming pregnant, to help alleviate complications including prenatal and postpartum depression and anxiety. Yet, no studies have examined how the process of losing weight prior to pregnancy interacts with the development of prenatal and postpartum mental health disorders.

Maternal Malnutrition During Pregnancy Among Women with Metabolic and Bariatric Surgery.

Introduction: As the utilization of metabolic and bariatric surgery (MBS) continues to rise, it is important to address the nutritional needs of women who had MBS who become pregnant. Not meeting those nutritional needs could lead to complications associated with malnutrition. To better understand the relationship between MBS, pregnancy, and malnutrition, this study sought to determine whether differences exist in the presence of malnutrition during pregnancy in women with a history of MBS compared to women without a history of MBS.

Stroke-related risk factors during pregnancy in women who underwent metabolic and bariatric surgery compared with women who have not undergone metabolic and bariatric surgery.

Background: Stroke during pregnancy is rare, occurring in 30 of 100,000 pregnancies and accounting for 7% of maternal deaths in the United States from 2016 to 2018. Metabolic and bariatric surgery (MBS) has been shown to reduce symptoms of chronic conditions that are risk factors for stroke, including hypertension, hypercholesterolemia, and diabetes in women. However, little is known about the impact of MBS on stroke risk during pregnancy.

Stroke and stroke risk factors in women of reproductive age with a history of metabolic or bariatric surgery.

Objective: To determine the odds of stroke in women of reproductive age who have had metabolic or bariatric surgery (MBS).

Methods: We used the National Inpatient Sample (NIS), a publicly available dataset that samples 20% of hospital discharges. The study population includes women between the ages of 20 and 44 without a maternal admission code.

Pregnancy Complications in Women with Weight Loss Surgery Compared to a Non-Surgical Population of Women with Obesity.

Background: The objective of this study was to assess the effect of WLS on pregnancy and delivery complications in women who had WLS compared to women with obesity who did not undergo WLS.

Methods: We used the National Inpatient Sample data from 2012 to 2017, with a study population of women between the ages of 20 and 44 who had a maternal admission code in the NIS data (n = 663,795). Weighted logistic regression models were fitted and the models were stratified by race.

What's Love Got to do with it? Marital status and survival of head and neck cancer.

Objective: To determine whether marital status independently predicts survival in a head and neck cancer (HNC) survivor population.

Methods: In this retrospective cohort study, we analysed data from 460 adult patients (59.31 ± 11.

Decreased cancer-independent life expectancy in the head and neck cancer population.

Background: Aside from cancer mortality, patients with head and neck cancer have increased mortality risk. Identifying patients with the greatest loss of cancer-independent life expectancy can guide comprehensive survivorship programs.

Methods: Age-based survival data from the Surveillance, Epidemiology, and End Result (SEER) database for patients with head and neck cancer were censored for mortality from the index cancer.

Competing causes of death in the head and neck cancer population.

Purpose/objectives: The increasing survivorship of head and neck squamous cell carcinoma (HNSCC) comes with a risk of death from other causes, known as competing causes. The demographics of HNSCC are also evolving with increasing incidence of Human Papillomavirus (HPV) associated tumors. This study describes competing causes of death for the HNSCC population compared to the general population and identifies associated risk factors.

Impact of treatment modality on quality of life of head and neck cancer patients: Findings from an academic medical institution.

Purpose: The objective of this pilot study was to determine how different treatment modalities (surgery, radiation, and chemotherapy) impact quality of life (QOL) in a population of head and neck cancer (HNC) survivors.

Methods: Fifty-nine newly diagnosed, biopsy-confirmed HNC patients were recruited between 2007-2012. They completed the EORTC Quality of Life Questionnaire and Head & Neck Module at 5 intervals pre- and post-treatment.

Botulinum Toxin Dosing Trends in Spasmodic Dysphonia Over a 20-year Period.

Objectives: The study aims to (1) identify the botulinum toxin (BTX) dosing trend in a cohort of patients who received at least 20 injections for the treatment of adductor spasmodic dysphonia (ADSD), (2) describe two distinct BTX dosing trends in treating ADSD (a "classic" dosing trend that initially decreases before stabilizing, and a "fluctuating" dosing trend), and (3) determine if patients with the "classic" dosing trend differed in age or in dosing intervals from those with the "fluctuating" dosing trend.

Study Design: This is a retrospective case series.

Methods: Of 149 patients who received a total of 2484 BTX injections for the treatment of spasmodic dysphonia in 1993-2013, 49 patients received at least 20 injections.

Predictors of stage at presentation and outcomes of head and neck cancers in a university hospital setting.

Background: To increase early detection of head and neck cancers, it is important that disparities associated with access to care are addressed.

Methods: A total of 351 patients aged 20 to 91 years (58.72 ± 11.

Race and sex disparities in long-term survival of oral and oropharyngeal cancer in the United States.

Purpose: To investigate the effect of race and sex on long-term survival of oral and oropharyngeal cancer.

Methods: The Surveillance, Epidemiology and End Results database was queried for adult oral and oropharyngeal cancer patients with at least 25-year follow-up. Kaplan-Meier survival curves and cox proportional hazards model were used to identify differences.

Efficacy of bone marrow cytologic evaluations in detecting occult cancellous invasion.

Objectives/hypothesis: Determine the accuracy of bone marrow cytologic evaluations in detecting occult cancellous invasion by squamous cell carcinomas (SCCa) beyond the original margins of bone resection that would have gone undetected without the use of intraoperative bone-marrow margin analysis.

Study Design: Retrospective single institution cohort study.

Methods: Retrospective chart review of imaging, clinical, pathological, and follow-up data of 51 patients who underwent mandibular resections with intraoperative bone-marrow cytologic evaluation.

Salvage surgery following radiation failure for laryngeal cancer in elderly patients.

Objective: To find the survival rate of patients ≥ 80 years old who undergo salvage surgery for squamous cell carcinoma of the larynx.

Study Design: National data registry analysis.

Setting: Seventeen population-based registries comprising the National Cancer Institute's Surveillance, Epidemiology, and End Results database.