Trace and non-trace elements in blood cells of bottlenose dolphins (Tursiops truncatus): variations with values from liver function indicators.

Alterations in trace and non-trace element homeostasis have been associated with both normal physiologic and pathologic processes of many species. Changes in copper and zinc, for instance, have been associated with liver disease in humans and dogs. While liver disease has been documented in marine mammals, associations of liver disease with trace and non-trace elements have not been determined.

Isolation, characterization, and expression of stromelysin-1 in primary tumors of dogs.

Objective: To isolate and characterize the cDNA sequence of canine stromelysin-1 (matrix metalloproteinase [MMPI-3), screen various naturally developing primary tumors of dogs, and assess the effect of stromelysin-1 on survival of dogs with cancer.

Sample Population: 3 canine cell lines and biopsy specimens of primary tumors collected from 54 dogs.

Procedure: 3 canine cell lines and biopsy specimens of primary tumors collected from 54 dogs at the University of Illinois Veterinary Teaching Hospital were used in the study.

Modulation of the genotoxicity of pesticides reacted with redox-modified smectite clay.

Pesticides are toxic agents intentionally released into the environment; their use raises public health and environmental concerns. In recent years there has been much attention to the biotic degradation of pesticides. Abiotic mechanisms in the soil can contribute to pesticide degradation yet the toxicological impact of such degradation is unclear.

Alteration of mammalian-cell toxicity of pesticides by structural iron(II) in ferruginous smectite.

The ultimate concern over pesticides in the environment is their toxic impact on nontarget organisms, including humans. Soil clays are known to interact with pesticides in ways that decrease the concentration of the parent compound in the soil solution (adsorption, sequestration, degradation). These phenomena are generally regarded as beneficial, but toxicological verification is lacking.

Expression of matrix metalloproteinases in feline vaccine site-associated sarcomas.

Objectives: To screen for expression of 9 predominant members of the matrix metalloproteinase (MMP) family, including membrane-type matrix metalloproteinases (MT-MMPs) and tissue inhibitors of metalloproteinases (TIMPs), in primary tumor tissue biopsy specimens of vaccine site-associated sarcomas (VSS) in cats and compare expression profiles of VSS with expression profiles of non-VSS and carcinomas.

Sample Population: 31 primary tumor tissue biopsy specimens and 6 nontumor (normal) tissue biopsy specimens.

Procedures: Tissue specimens were obtained from primary tumor biopsy specimens of cats.

Isolation, characterization, and expression of feline stromelysin-1 in naturally developing tumors in cats.

Objective: To detect, isolate, and characterize feline stromelysin-1 (ie, matrix metalloproteinase [MMP]-3) in naturally developing tumors in cats.

Sample Population: 31 tissue samples obtained from primary tumors and 6 samples of normal tissues from cats.

Procedure: Biopsy specimens were obtained from primary tumors.