Publications by authors named "Kar-Man Chan"

Perioperative pulmonary aspiration is a critical complication linked to significant morbidity and mortality, particularly in high-risk populations such as patients with diabetes, obesity, gastroparesis, or those using Glucagon-Like-Peptide-1 receptor agonists (GLP-1 RAs). Standard fasting protocols may not be appropriate for these patients, as they have increased propensity of delayed gastric emptying, hence increasing the complex of the preoperative risk assessment. Gastric ultrasound (GUS) provides a non-invasive, reliable method for assessing gastric content and volume, enabling anaesthesia professionals to make informed decisions regarding aspiration risk, airway management, and surgical scheduling.

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According to Chinese Pharmacopoeia 2015 edition, Ganoderma (Lingzhi) is a species complex that comprise of Ganoderma lucidum and Ganoderma sinense. The bioactivity and chemical composition of G. lucidium had been studied extensively, and it was shown to possess antitumor activities in pharmacological studies.

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Turmeric is commonly used as a medicinal herb and dietary supplement. Its active ingredient, curcumin, has been shown to possess antitumor effects in colorectal cancer patients. However, poor absorption of curcumin in intestine impedes its wide clinical application.

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Esophageal cancer is the sixth most common cancer in male causing death worldwide. It is usually diagnosed at advanced stage with high postoperative recurrence and systemic metastasis, which leads to poor prognosis. The potential inhibitory effect of herbal medicines on metastasis of esophageal cancer has drawn researchers' great attention.

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The dried roots of Cynanchum stauntonii in having cough-relieving efficacy are commonly included in traditional antitussive formulas. The active components in a C. stauntonii root extract responsible for airway relaxation were isolated using an ex vivo bioassay-guided fractionation method, in which subfractions were evaluated for their inhibitory effects on the contraction of isolated rat tracheal rings by isometric tension measurements.

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A new family of heteroditopic calix[4]diquinone receptors capable of the cooperative recognition of ion-pair species through a contact binding mechanism has been developed. The receptors bind contact ion pairs cooperatively, with an unprecedented AND recognition phenomenon being observed to operate in certain cases, in which receptors display no affinity for either of the individual "free" cation or anion, but bind the cation and anion ion-pair strongly. X-ray crystallographic, solution-state, and computational methods rationalize the observed recognition behavior of the receptors.

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