Protein arginylation mediated by arginyltransferase 1 is a crucial regulator of cellular processes in eukaryotes by affecting protein stability, function, and interaction with other macromolecules. This enzyme and its targets are of immense interest for modulating cellular processes in diseased states like obesity and cancer. Despite being an important target molecule, no highly potent drug against this enzyme exists.
View Article and Find Full Text PDFAim: The present study is aimed to compare the effectiveness of dentinal tubule occlusion of two natural-based desensitizing toothpaste (Bentodent Desensitizer and Fang Farm Mint) and Novamin-based toothpaste (Shy-NM) under scanning electron microscope (SEM).
Materials And Methods: A total of 60 root dentin discs (3 mm-thick) were obtained from recently extracted permanent premolar teeth and were randomly divided into four groups based on the desensitizing toothpaste used, each group with 15 samples: Group I: Control, group II: Shy-NM, group III: Bentodent desensitizer, group IV: Fang Farm Mint. Samples were brushed for 2 min twice daily with a soft toothbrush with respective pea size amount of toothpaste for 14 days manually.
Recently, lead halide perovskites have shown great potential in the photodetection field. Unfortunately, the existence of toxic lead elements restricts their practical application. Herein, high-quality 1D lead-free crystals RbCuX (X = Cl, Br) are successfully synthesized in an acidic medium.
View Article and Find Full Text PDFA critical cell cycle checkpoint for most bacteria is the onset of constriction when the septal peptidoglycan synthesis starts. According to the current understanding, the arrival of FtsN to midcell triggers this checkpoint in Escherichia coli. Recent structural and in vitro data suggests that recruitment of FtsN to the Z-ring leads to a conformational switch in actin-like FtsA, which links FtsZ protofilaments to the cell membrane and acts as a hub for the late divisome proteins.
View Article and Find Full Text PDFIndian J Med Microbiol
December 2024
Cesium-lead-halide (Cs-Pb-Br) perovskites have been a point of interest for researchers since their discovery for their extraordinary optical and electronic properties. Unlike other members of the Cs-Pb-Br family, CsPbBr is less explored. Herein, we synthesized 2D CsPbBr in an aqueous medium under ambient conditions.
View Article and Find Full Text PDFThe toxic Cr(VI) contaminating water released from the metallurgical, dyeing, and electroplating industries is getting worse day by day and is extremely hazardous to human health. Thus, the development of a cost-effective, quick, and efficient adsorbent is highly essential for the Cr(VI) decontamination from wastewater. Herein, a microwave-assisted carbon-based composite called Mg-Fe LDH@OPAC was prepared by assembling Mg-Fe LDH onto orange peel-activated carbon (OAPC).
View Article and Find Full Text PDFThe spleen tyrosine kinase (Syk) is a key regulator in immune cell signaling and is linked to various mechanisms in cancer and neurodegenerative diseases. Although most computational research on Syk focuses on novel drug design, the molecular-level regulatory dynamics remain unexplored. In this study, we utilized 5 × 1 μs all-atom molecular dynamics simulations of the Syk kinase domain, examining it in combinations of activation segment phosphorylated/unphosphorylated (at Tyr525, Tyr526) and the "DFG"-Asp protonated/deprotonated (at Asp512) states to investigate conformational variations and regulatory dynamics of various loops and motifs within the kinase domain.
View Article and Find Full Text PDFEthnopharmacological Relevance: Tecoma stans (L.) Juss.ex Kunth (Bignoniaceae) is mainly found in tropical and subtropical regions of Africa and Asia.
View Article and Find Full Text PDFThe senescence phenotype is heterogeneous, as observed by the context-dependent differential expression of senescence markers. Here, we provide evidence to demonstrate an inverse relationship in the expression pattern of the two murine variants of p21 (p21v1, and p21v2) in aging and hemorrhagic shock. While an upregulation of p21v1 was observed following hemorrhagic shock injury, p21v2 was upregulated in the aged mouse.
View Article and Find Full Text PDFIn this study conducted along the coast of Odisha, India, reproductive trade-offs in isopods of the family Cymothoidae were investigated, focusing on the relationship between the number vs. volume of eggs and the percentage of brood to body volume. Ovigerous females from species with substantial sample sizes (n > 30) were analyzed to understand their survival strategies.
View Article and Find Full Text PDFAim: It was aimed to determine the potential effect of Lactobacillus acidophilus supplementation on rats exposed to an experimental high-fat diet on serum lipid profile and kidney total beta amyloid protein (TBAP) and Tumor Necrosis Factor-alpha (TNF-α) levels.
Methods: 24 male Sprague-Dawley rats were used in the study to establish 4 groups. Standard rat food (SD) was provided to Group 1 as the control; Group 2 was fed a high-fat diet (HFD); Group 3 consumed SD and received L.
Background: The Surinam cherry, belongs to the family Myrtaceae, an edible fruit-bearing medicinal plant with various biological properties. Several anticancer studies have been conducted on its essential oils while the non-essential oil compounds including phenolics, flavonoids, and carotenoids have not been fully investigated.
Purpose: Therefore, the study evaluated the in silico anticancer potentials of phenolic, flavonoid, and carotenoid compounds of against the MDM2 and Bcl-xL proteins, which are known to promote cancer cell growth and malignancy.
Pediatric patients with osteomyelitis, a serious bone infection, have several difficulties. A 12-year-old child with an acute osteomyelitis diagnosis is the subject of this case study. The child had decreased limb function, a fever, and localized pain.
View Article and Find Full Text PDFThe tunable molecular scaffold of organic moieties in metallopolymers generates variation in their properties, but what could be the minimal change that can produce variation in the properties of these macromolecules is still untouched. This research has meticulously explored the trivial change in the molecular scaffold of the ligand capable of making a mammoth difference in the nonvolatile memory and coordination pattern in two metallopolymers. The significance of this research lies in the fact that it demonstrates how a slight change in the organic building block can significantly alter the memristive and fluorescence properties of iron(II) metallopolymers, opening up new possibilities for their design and synthesis.
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