Publications by authors named "Kar P"

Protein arginylation mediated by arginyltransferase 1 is a crucial regulator of cellular processes in eukaryotes by affecting protein stability, function, and interaction with other macromolecules. This enzyme and its targets are of immense interest for modulating cellular processes in diseased states like obesity and cancer. Despite being an important target molecule, no highly potent drug against this enzyme exists.

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Aim: The present study is aimed to compare the effectiveness of dentinal tubule occlusion of two natural-based desensitizing toothpaste (Bentodent Desensitizer and Fang Farm Mint) and Novamin-based toothpaste (Shy-NM) under scanning electron microscope (SEM).

Materials And Methods: A total of 60 root dentin discs (3 mm-thick) were obtained from recently extracted permanent premolar teeth and were randomly divided into four groups based on the desensitizing toothpaste used, each group with 15 samples: Group I: Control, group II: Shy-NM, group III: Bentodent desensitizer, group IV: Fang Farm Mint. Samples were brushed for 2 min twice daily with a soft toothbrush with respective pea size amount of toothpaste for 14 days manually.

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  • ALS is a motor neuron disease that causes the gradual degeneration of both upper and lower motor neurons, typically affecting individuals over 60 years old.
  • A rare case of ALS is presented involving a 31-year-old woman who experienced progressive limb weakness and muscle wasting.
  • The study highlights notable MRI findings, specifically the "wine glass sign," in the context of this unusual early-onset ALS case.
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Recently, lead halide perovskites have shown great potential in the photodetection field. Unfortunately, the existence of toxic lead elements restricts their practical application. Herein, high-quality 1D lead-free crystals RbCuX (X = Cl, Br) are successfully synthesized in an acidic medium.

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A critical cell cycle checkpoint for most bacteria is the onset of constriction when the septal peptidoglycan synthesis starts. According to the current understanding, the arrival of FtsN to midcell triggers this checkpoint in Escherichia coli. Recent structural and in vitro data suggests that recruitment of FtsN to the Z-ring leads to a conformational switch in actin-like FtsA, which links FtsZ protofilaments to the cell membrane and acts as a hub for the late divisome proteins.

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  • The study investigates how Mycobacterium tuberculosis (Mtb) grows differently compared to other bacteria, particularly focusing on its cell growth patterns and behaviors at the single-cell level.
  • Using time-lapse imaging and mathematical modeling, it was found that Mtb has an asymmetric growth pattern and displays variability in cell size, growth speed, and division times.
  • Unlike typical bacteria that grow exponentially, Mtb grows in a linear fashion, indicating that its growth regulation mechanisms might differ significantly from those of other bacterial species.
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  • A 3-year-old boy undergoing treatment for disseminated tuberculosis developed scalp swelling, prompting a needle aspirate.
  • The aspirate identified yeasts inside macrophages, initially misdiagnosed as Histoplasmosis but later confirmed as Cryptococcosis.
  • Treatment with liposomal amphotericin B and fluconazole led to the resolution of lesions, marking this as a rare pediatric case of cryptococcosis from Odisha.
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Cesium-lead-halide (Cs-Pb-Br) perovskites have been a point of interest for researchers since their discovery for their extraordinary optical and electronic properties. Unlike other members of the Cs-Pb-Br family, CsPbBr is less explored. Herein, we synthesized 2D CsPbBr in an aqueous medium under ambient conditions.

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The toxic Cr(VI) contaminating water released from the metallurgical, dyeing, and electroplating industries is getting worse day by day and is extremely hazardous to human health. Thus, the development of a cost-effective, quick, and efficient adsorbent is highly essential for the Cr(VI) decontamination from wastewater. Herein, a microwave-assisted carbon-based composite called Mg-Fe LDH@OPAC was prepared by assembling Mg-Fe LDH onto orange peel-activated carbon (OAPC).

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  • Children exposed to alcohol before birth (PAE) may face neurological and behavioral challenges, particularly with reading and language skills.
  • Researchers studied brain scans and pre-reading abilities in 135 children aged 3-7, including 53 with PAE, using diffusion MRI and assessments like NEPSY-II.
  • Findings revealed that children with PAE scored lower on reading tests and showed different brain network properties compared to those not exposed, indicating brain changes linked to their reading difficulties.
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The spleen tyrosine kinase (Syk) is a key regulator in immune cell signaling and is linked to various mechanisms in cancer and neurodegenerative diseases. Although most computational research on Syk focuses on novel drug design, the molecular-level regulatory dynamics remain unexplored. In this study, we utilized 5 × 1 μs all-atom molecular dynamics simulations of the Syk kinase domain, examining it in combinations of activation segment phosphorylated/unphosphorylated (at Tyr525, Tyr526) and the "DFG"-Asp protonated/deprotonated (at Asp512) states to investigate conformational variations and regulatory dynamics of various loops and motifs within the kinase domain.

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Ethnopharmacological Relevance: Tecoma stans (L.) Juss.ex Kunth (Bignoniaceae) is mainly found in tropical and subtropical regions of Africa and Asia.

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The senescence phenotype is heterogeneous, as observed by the context-dependent differential expression of senescence markers. Here, we provide evidence to demonstrate an inverse relationship in the expression pattern of the two murine variants of p21 (p21v1, and p21v2) in aging and hemorrhagic shock. While an upregulation of p21v1 was observed following hemorrhagic shock injury, p21v2 was upregulated in the aged mouse.

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In this study conducted along the coast of Odisha, India, reproductive trade-offs in isopods of the family Cymothoidae were investigated, focusing on the relationship between the number vs. volume of eggs and the percentage of brood to body volume. Ovigerous females from species with substantial sample sizes (n > 30) were analyzed to understand their survival strategies.

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Aim: It was aimed to determine the potential effect of Lactobacillus acidophilus supplementation on rats exposed to an experimental high-fat diet on serum lipid profile and kidney total beta amyloid protein (TBAP) and Tumor Necrosis Factor-alpha (TNF-α) levels.

Methods: 24 male Sprague-Dawley rats were used in the study to establish 4 groups. Standard rat food (SD) was provided to Group 1 as the control; Group 2 was fed a high-fat diet (HFD); Group 3 consumed SD and received L.

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Background: The Surinam cherry, belongs to the family Myrtaceae, an edible fruit-bearing medicinal plant with various biological properties. Several anticancer studies have been conducted on its essential oils while the non-essential oil compounds including phenolics, flavonoids, and carotenoids have not been fully investigated.

Purpose: Therefore, the study evaluated the in silico anticancer potentials of phenolic, flavonoid, and carotenoid compounds of against the MDM2 and Bcl-xL proteins, which are known to promote cancer cell growth and malignancy.

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  • Captopril, widely used to treat various cardiovascular conditions, shows potential for bladder cancer patients with hypertension due to its interaction with relevant proteins associated with the disease.* -
  • The study identified key protein targets of captopril using Bioinformatics tools, revealing that it effectively inhibits overexpressed genes like MMP9 and LCN2, which are linked to poor survival rates in bladder cancer.* -
  • The research suggests further laboratory studies are needed to validate captopril's effectiveness in treating bladder cancer, highlighting its dual role in managing both hypertension and cancer-related complications.*
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Pediatric patients with osteomyelitis, a serious bone infection, have several difficulties. A 12-year-old child with an acute osteomyelitis diagnosis is the subject of this case study. The child had decreased limb function, a fever, and localized pain.

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The tunable molecular scaffold of organic moieties in metallopolymers generates variation in their properties, but what could be the minimal change that can produce variation in the properties of these macromolecules is still untouched. This research has meticulously explored the trivial change in the molecular scaffold of the ligand capable of making a mammoth difference in the nonvolatile memory and coordination pattern in two metallopolymers. The significance of this research lies in the fact that it demonstrates how a slight change in the organic building block can significantly alter the memristive and fluorescence properties of iron(II) metallopolymers, opening up new possibilities for their design and synthesis.

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