Validation of SCORE2 on a sample from the Russian population and adaptation for the very high cardiovascular disease risk region.

SCORE2 (Systematic COronary Risk Evaluation 2) is a risk assessment scale for cardiovascular events, presented in 2021 by the European Society of Cardiology. Both for training and validation of the SCORE2 model, representative samples from the Russian population were not used. Therefore, we aimed to validate SCORE2 on a such sample.

Copper(II) coordination compounds based on bis-hydrazones of 2,6-diacetylpyridine: synthesis, structure, and cytotoxic activity.

By reacting a series of 2,6-diacetylpyridine bis-hydrazones containing pyrimidine (H2L1), benzimidazole (H2L2) and phthalazine (H2L3) heterocyclic fragments with copper(II) chloride and bromide, a variety of pentacoordinated complexes of the composition , and , where X = Cl, Br, are formed. The properties and structure of the compounds were studied by means of NMR, IR, UV-vis, ESR, and X-ray absorption spectroscopy, cyclic voltammetry and X-Ray single crystal diffraction methods. It was shown that complexes of the cationic type have an asymmetric structure with a distorted square-pyramidal geometry of the coordination unit.

Regional Living Conditions and Individual Dietary Characteristics of the Russian Population.

The goal of our study was to examine the effects of the regional characteristics of the living environment on individual a priori and a posteriori dietary patterns of the Russian population. For the analysis, we used cross-sectional data from the Epidemiology of Cardiovascular Diseases in the Regions of the Russian Federation study from 2013-2014. The sample included 18,054 men and women 25-64 years of age from 12 regions.

Characterization of blood biomarkers in prospective follow-up of patients with cardiovascular pathology in combination with type 2 diabetes mellitus after COVID-19 associated pneumonia.

The study of the characteristics and dynamics of laboratory biomarkers in patients with cardiovascular diseases (CVD) with type 2 diabetes mellitus who underwent COVID-19-associated pneumonia is of great clinical importance for preventing the risk of adverse events. IN the study we used data from 65 patients in the present work. Patients were divided into 2 groups: group 1 included patients with CVD: arterial hypertension (AH) in combination with coronary artery disease (CAD) without DM2 (n=45), group 2 included patients with CVD and DM2 (n=20).

Regional living conditions and the prevalence, awareness, treatment, control of hypertension at the individual level in Russia.

Background: The objective of our study was to investigate the associations of characteristics inherent in large Russian Federation (RF) regions with prevalence, awareness, treatment and control of hypertension at the individual level.

Methods: Regional characteristics were obtained from the official website of the Federal State Statistics Service of the RF. We employed principal component analysis to reduce the dimensionality of data, which allowed defining five integral regional indices.

Estimation of erythrocyte parameters of general blood analysis in patients with SARS-CoV-2 -associated pneumonia.

The study of the features and dynamics of the erythrocyte parameters of general blood analysis in patients with cardiovascular diseases who underwent SARS-CoV-2 associated pneumonia is of great practical importance. That was a prospective study. The study included 106 patients with SARS-CoV-2-associated pneumonia.

[Left ventricular global function index as a predictor of adverse cardiovascular events in patients with acute coronary syndrome].

Aim      To evaluate the prognostic significance of the left ventricular global function index (LV GFI) in patients with acute coronary syndrome (ACS) using echocardiography (EchoCG).Material and methods             The LV GFI is an index that integrates LV cavity volumes, stroke volume, and myocardial volume. This study included 2169 patients with ACS (1340 (61.

The extent and nature of television food advertising to children and adolescents in the Russian Federation.

Objective: To assess the frequency, healthfulness and promotional techniques of television food advertising to children and adolescents in the Russian Federation.

Design: A cross-sectional study was conducted to monitor food and beverage television advertising. For the five most popular TV channels among children and adolescents, TV broadcasts were recorded for two weekdays and two weekends (320 h) during March-May 2017.

[Empirical dietary patterns in the Russian population and the risk factors of chronic non-infectious diseases (Research ECVD-RF)].

Currently, in the epidemiology of nutrition, methodological approaches to the empirical assessment of the diets of the population and their relationship to health indicators are actively using. In Russia, these approaches have been used in a number of cohort and regional studies, however, such studies are not available for the entire Russian population. .

[The Prediction Model of Cardiovascular Events Among the Russian Population: Methodological Aspects].

Unlabelled: Modeling is the common approach for predicting not only the population health, but also the social and economic burden of disease, which is an important argument while making decisions in health care and prevention.

Aim: To develop the model for predicting cardiovascular risk, applicable for the assessment of clinical and socio-economic effects of preventive and therapeutic actions at the level of the whole population or part (region, city, group of patients).

Material And Methods: An analytical model for making decision was performed by using a Markov model consisting of Markov states and probabilities of transition from one state to another within a certain time interval.

[Physiologic features of adaptation in Middle Asia migrants working on Moscow region territory.].

The article presents results of physiologic studies of nine occupational groups of migrants from south republics of Middle Asia to Moscow region of Russian Federation. The authors revealed features of cardiac rhythm regulation variability in the migrants in accordance with physical exertion value and psychoemotional characters of work. Optimization of the adaptation processes should get along with organization of rational work and rest schedule, healthy lifestyle formation, better medical service to the migrants.

[Association of Atrial Fibrillation With Mortality From Various Causes in Population of Russian Federation].

Aim: to elucidate contribution of atrial fibrillation (AF) to mortality from various causes among men and women in Russia.

Material And Methods: We analyzed data from samples of population of Moscow and Petersburg (Leningrad) aged 35-74 years examined in different years. Total number of subjects was 20045 (15107 men), response rate was 75%.

[Epidemiological Situation With Main Risk Factors of Cardio-Vascular Diseases Among Young Adults in Russian Federation].

to assess dynamics of cardiovascular risk factors (RF) among young adults in some regions of Russian Federation on the basis of arterial hypertension monitoring conducted in 2003-2010. Data on blood pressure (BP), weight, height, total cholesterol level as well.

[The physiological features of overstrain formation in mental work and its prevention].

Psychophysiological and biochemical studies have shown that significant neuro- emotional loads produce such functional status, which can be called overstrain. It was found out at the first time that the physiological and biochemical characteristics of overstrain based on the main parameters in mental work. The research proved the preventive measures of human body overstrain and can help to prevent the diseases related to work.

[Forecasting decrease in performance and health disorders under exposure to work intensity factors in accordance with work conditions class].

Results of complex physiologic and ergonomic, clinical and functional studies helped to justify approaches to quantitative evaluation and assessment of posssible decrease in performance and health disorders in workers in accordance with work conditions class of mental work. Linear regression dependence was established between work intensity class and performance decrease. The linear regression equation obtained enables to calculate a percentage of performance decrease in various work intensity classes.

[Labor physiology role in workers of different type labor activity workability and health. Progress and prospects].

There are presented the data of workers overstrain and fatigue conditions mechanisms based on physiological, psychological and ergonomic aspects of work processes in different types of activities (mental, visual-strained, physical). 15-year historical analysis, current state and prospects of labor physiology methods development are shown. Complex physiological and ergonomic investigations have allowed developing the measures of work ability raise and diseases prevention for workers various professions.

Major approaches in early diagnostics of common variable immunodeficiency in adults in Moscow.

Common variable immunodeficiency (CVID) is a primary immunological disease characterized predominantly by hypogammaglobulinemia. The main clinical manifestations are severe recurrent infections that often lead to structural damage of affected organs. The early start of adequate intravenous immunoglobulin therapy has significantly improved the prognosis of this serious disorder.

[Physiologic and ergonomic aspects of social and hygienic monitoring of workers' performance and health].

The article tackles necessity of physiologic and ergonomic research in system of social and hygienic monitoring of workers' performance and health. A presented scheme covers physiologic and ergonimic aspects: monitoring of work process factors; monitoring of workers' performance and functional state. The authors formulated theoretic orientation of the problem and demonstrated scientific and practical importance of physiologic and ergonomic monitoring.

[Features of overexertion formation due to high psychoemotional strain and shift work].

Physiologic studies proved that considerable psychoemotional load in shift work and longer working shifts lead to the certain functional state called overexertion. The authors are first to set biochemical and physiologic characteristics by main parameters for this state in mental workers. According to the authors, physiologic features of overexertion should be evaluated from the viewpoint of coordinated diurnal rhythms, internal and intersystem communications in central nervous and cardiovascular systems, functional levels.

[Pulse rate and cardiovascular mortality of men and women in Russia. Results of epidemiological studies].

Aim: To assess relationship between pulse rate (PR) and cardiovascular and total mortality in samples of male and female population of Russia.

Material And Methods: Results of several cross-sectional and cohort studies carried out on different years by Research Center of Preventive Medicine of Ministry of Health of Russian Federation were pooled. Overall 10,109 men and 4,668 women aged > or = 35 years were followed for 18 and 16 years, respectively.

[Alcohol consumption and its connection with mortality from cardiovascular diseases in 40-59 years old men (data from 21.5 year prospective study)].

Aim: To study contribution of alcohol consumption (AC) to mortality of coronary heart disease (CHD), cerebral stroke (CS), cardiovascular diseases (CVD), overall mortality (OM) in a random population of working males.

Material And Methods: The results are available of a 21.5 year cohort study of mortality in a random population of 7,815 male citizens of Moscow and St-Petersburg aged 40-59 years.

[Prevalence of excessive body mass and its relation to mortality from cardiovascular and main chronic noninfectious diseases among urban male population of geographical different regions in Russia].

The paper contains data on prevalence of low, normal, excessive body mass and obesity among urban male populations aged 20-54 years in different regions. Relative risk of death associated with body mass was estimated on the basis of a twenty years prospective study of sample populations in Moskva and St-Peterburg and level of attributed risk was used for assessment of contribution of body mass to cardiovascular mortality and mortality from other chronic diseases. Levels of main risk factors, smoking intensity and alcohol consumption were studied in deciles of body mass index distribution.