Creation and Evaluation of a Severity Classification of Hyperkyphosis and Hypolordosis for Exercise Therapy.

The rise in the occurrence of musculoskeletal disorders, such as thoracic hyperkyphosis (THK) or lumbar hypolordosis (LHL), is a result of demographic changes. Exercise therapy is an effective approach that can reduce related disabilities and costs. To ensure successful therapy, an individualized exercise program adapted to the severity of the disorder is expedient.

Molecular analysis of aniridia patients for deletions involving the Wilms' tumor gene.

A human aniridia candidate (AN) gene on chromosome 11p13 has been cloned and characterized. The AN gene is the second cloned gene of the contiguous genes syndrome WAGR (Wilms' tumor, aniridia, genitourinary malformations, mental retardation) on chromosome 11p13, WT1 being the first gene cloned. Knowledge about the position of the AN and WT1 genes on the map of 11p13 makes the risk assessment for Wilms' tumor development in AN patients possible.

[Clinico-histopathologic correlation of ganciclovir-treated cytomegalovirus retinitis].

A 46 year old AIDS-patient, who had developed CMV-retinitis was treated with the virostatic drug dihydroxypropoxymethylguanine (DHPG, Ganciclovir) over a period of 16 months until he died due to a pneumonia. After the DHPG-treatment was initiated the retinitis improved markedly, however there still was a very slow progression of the disease in the following time. The central retina of both eyes was not affected until death.

[Ganciclovir (DHPG)--treatment of cytomegalovirus retinitis in AIDS].

The clinical course of 3 patients treated with the virostatic drug dihydroxypropoxymethylguanine (DHPG) is reported. With maintenance therapy the progression of retinitis was slow, but was not stopped. More rapid progression of retinitis could be observed after cessation of therapy because of DHPG-induced leukopenia.