Transscleral Selective Laser Trabeculoplasty Without a Gonioscopy Lens.

Purpose Of The Study: The purpose of the study was to investigate results of selective laser trabeculoplasty (SLT) performed directly on the sclera without a gonioscopy lens.

Design: Interventional case series, prospective, randomized, masked, controlled clinical trial.

Methods: Setting: Meir Medical Center, Kfar-Saba, Israel.

Selective laser trabeculoplasty in uncontrolled pseudoexfoliation glaucoma.

Background And Objective: To assess the efficacy and safety of selective laser trabeculoplasty (SLT) in uncontrolled pseudoexfoliation glaucoma (PEXG).

Patients And Methods: Fifty-seven eyes (57 patients) with uncontrolled PEXG and intra-ocular pressure (IOP) greater than 23 mm Hg underwent SLT. All received ophthalmic evaluation preoperatively and at intervals postoperatively.

Quantifying retinal nerve fiber layer loss in glaucoma using a model of unilateral hypertensive pseudoexfoliation syndrome.

Purpose: To correlate the amount of glaucomatous field loss with amount of retinal nerve fiber layer (RNFL) loss using a novel model consisting of eyes of subjects with pseudoexfoliation syndrome (PXS) in 1 eye only with elevated intraocular pressure, using the fellow eye as a marker of baseline healthy anatomy, allowing precise correlation by elimination of intersubject anatomic variation.

Methods: In each eye with PXS we recorded standard automated perimetry mean deviation and the percentage loss of Stratus optical coherence tomography - RNFL thickness relative to the fellow non-PXS eye, and correlated these 2 measurements.

Results: Twenty-six subjects with unilateral hypertensive PXS were enrolled.

Trabeculectomy and phaco-trabeculectomy with and without peripheral iridectomy.

Purpose: To compare the 1-year outcome of trabeculectomy and combined phaco-trabeculectomy that were performed with or without a peripheral iridectomy (PI).

Methods: In a large tertiary glaucoma clinic, with a single surgeon performing all surgeries, 47 patients scheduled to undergo either a primary trabeculectomy or phaco-trabeculectomy were prospectively randomized to surgery with or without peripheral iridectomy. Other than the inclusion (PI group) or omission (no PI group) of a PI, surgical technique and postoperative care were identical for the two groups.

Methotrexate as a first-line corticosteroid-sparing therapy in a cohort of uveitis and scleritis.

Purpose: To evaluate the clinical experience with methotrexate as a first-line corticosteroid-sparing drug in patients with resistant ocular inflammation.

Methods: We retrospectively studied 39 consecutive patients with uveitis (n = 36) or scleritis (n = 3) who were treated with methotrexate following inadequate control with corticosteroids lasting five years. Criteria for initiating treatment with methotrexate and defining outcome were strictly defined.

Ocular hypotensive effects of cholinergic and adrenergic drugs may be influenced by prostaglandins E2 in the human and rabbit eye.

Purpose: Increased PGE2 production by the iris and ciliary body regulate intraocular pressure (IOP) in vivo. Various cholinergic and adrenergic compounds are traditionally used as antiglaucoma drugs, and their effect on IOP reduction is antagonised by cyclooxygenase inhibitors, indicating a role for eicosanoids in their hypotensive activity. One of the most potent antiglaucoma drugs, PG2 alpha (Latanoprost), reduces IOP by increasing uveoscleral outflow and also increases PGE2 production by the iris and ciliary body in vivo.

Mechanism related to reduction of intraocular pressure by melanocortins in rabbits.

Aim: To investigate whether the ocular hypotensive effect of alpha melanocyte stimulating hormone (MSH) is related to eicosanoids or cyclic AMP (cAMP).

Methods: Intraocular pressure (IOP) readings were taken at a similar time on the day before and after a single dose of topical MSH. Changes in the levels of prostaglandin E(2) (PGE(2)) and prostacyclin in incubated iris ciliary body (ICB) explants were measured by specific radioimmunoassay (RIA).

[Computerized video-keratoscopic analysis and cataract surgery by phacoemulsification. Predictive calculation of the power of the intraocular implant].

Purpose: The authors present the results of a prospective study of 125 consecutive cases of phacoemulsification, performed by a single surgeon, to assess the benefit of computerised videokeratoscopy for the improvement of the predictive calculation of the power of intraocular lenses (IOL).

Methods: Preoperative keratometry was determined by means of 3 concurrent techniques, including automated kerato-refractometry (AKR 2000, Nidek) and videokeratoscopy by TMS-1 (Tomey) and CAS-1 (EyeSys). The results of the IOL calculation by these 3 methods was compared postoperatively to the power of the actual IOL yielding emmetropia as calculated by the optical method based on the postop, refraction at the various time-points.