Publications by authors named "Kapl S"
Substitution of lost neurons by neurotransplantation would be a possible management of advanced degenerative cerebellar ataxias in which insufficient cerebellar reserve remains. In this study, we examined the volume and structure of solid embryonic cerebellar grafts in adult Lurcher mice, a model of olivocerebellar degeneration, and their healthy littermates. Grafts taken from enhanced green fluorescent protein (EGFP)-positive embryos were injected into the cerebellum of host mice.
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- * This study examined edaravone’s potential effects on SCA1 using a mouse model over 13 weeks, assessing various functional and behavioral deficits.
- * The findings indicated that edaravone did not show any significant therapeutic benefits in improving behavioral dysfunctions or related disease symptoms in the SCA1 mice, challenging its potential as a treatment for this condition.
The hippocampus plays a crucial role in the formation and retrieval of spatial memory across mammals and episodic memory in humans. Episodic and spatial memories can be retrieved irrespective of the subject's awake behavioral state and independently of its actual spatial context. However, the nature of hippocampal network activity during such out-context retrieval has not been described so far.
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