Publications by authors named "Kapila B Gaikwad"
Background: Cardiometabolic disorders, notably primary hypertension and type 2 diabetes, present substantial global health challenges. The intricate interplay between metabolic and cardiovascular pathways has prompted extensive research into molecular mechanisms linking these conditions. The adipokine Retinol Binding Protein 4 (RBP4), initially recognized for retinol transport, has emerged as a potential biomarker in the network of metabolic and cardiovascular dysfunction.
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- Hypertension is a common issue during pregnancy, specifically characterized as Pregnancy Induced Hypertension (PIH), linked to changes in endothelial function and nitric oxide levels.
- Research aimed to investigate the role of reactive nitrogen species in PIH, comparing 60 patients with PIH to 60 without.
- The study found lower nitric oxide levels, higher S-nitrothiol levels, and decreased thiol levels in PIH patients, suggesting that nitrosative stress may play a key role in the development of PIH due to antioxidant depletion.